What is/are the role(s) of the cyclin subunit of cyclin-dependent protein kinases?
a) it determines the substrate specificity of the kinase
b) it is an allosteric modulator of the kinase
c) it is absolutely required for kinase activity
d) all of the above
e) none of the above
What is/are the role(s) of the cyclin subunit of cyclin-dependent protein kinases? a) it determines the...
Which of the following transitions in the cell cycle is not controlled by a cyclin-dependent kinase? Select one: a. none of the above - they are all controlled by a cyclin-dependent kinase b. G1 to c. metaphase to anaphase d. G1 restriction point e. G2 to M
Explain the central role played by CdK (cell cycle-dependent kinases) in the transition from G1 to S and preRC to preIC at DNA origins of replication. Use the diagram below for help RC ORC Cyclin A/B+ Cdk APC Licensed DNA Rb DNA replication MCM ORC Rb S G1 D cyclins Cdk4/6 Cyclin A Cdk2 Cyclin E+Cdk2 ORC DNA licensing inactivation Skp2 CUL4 → Cok
What are the roles of the retinoblastoma protein (Rb)? a) it acts as a tumor suppressor b) it is an inhibitor of cell proliferation c) it is a substrate for cyclin dependant kinases that inactivate Rb d) all of the above
4. Short response (2 sentences max, 6pts each) A. Many yeast species have only one cyclin-dependent kinase (Cdk), which activates protein targets that drive events in multiple phases of the cell cycle. Why doesn't this Cdk activate G1-, S-, G2-, and M-phase proteins all at the same time? B. Please describe how cell death by apoptosis can play a beneficial role in the body's healthy growth. C. For a cell starting in G1, place the following cell cycle events in...
4. Short response (2 sentences max, 6pts each) A. Many yeast species have only one cyclin-dependent kinase (Cdk), which activates protein targets that drive events in multiple phases of the cell cycle. Why doesn't this Cdk activate G1-, S-, G2-, and M-phase proteins all at the same time? B. Please describe how cell death by apoptosis can play a beneficial role in the body's healthy growth. C. For a cell starting in G1, place the following cell cycle events in...
Les one phonphate A) (3 pts) What is the role of fructose 6-phosphate in the PFK catalyzed reaction as seen in graph Arch (A) Substrate; (B) Allosteric inhibitor; (C) Allosteric activator; (D) None of the above B) (3 pts) What is the role of fructose 2.6-bisphosphate (F-2,6-BP) in the PFK catalyzed reaction as seen Choose between: (A) Substrate; (B) Allosteric inhibitor; (C) Allosteric activator; (D) None of the above C) (4 pts) What are the 2 roles of ATP in...
The Maturation promoting factor (MPF) is a complex formed by a cyclin dependent kinase (CDK) and a cyclin. MPF allows for the transition from G2 to M checkpoint. A mutation preventing the binding of cyclin to CDK will... Select one: a result in more cells arrested in the G2 to M checkpoint b. cause uncontrolled cell division and eventually a tumor c. More than one listed option are possible consequences of this event d. increase in the phosphorylation of the...
O) The role of the 23S TRNA of the large ribosomal subunit of E. coli during protein synthesis is: a. aid in initiation of protein synthesis b. contributes to the process of translocation during the elongation stage of protein synthesis c. helps to form the A site within the ribosome d. actively forms a peptide bond e. none of the above P) Spontaneous mutations can be caused by: a. incorrect translation b. telomerase c. chemical mutagens d. tautomeric shifts e....
6.) Mitogens are (b) transcription factors important for cyclin production (c) kinases that cause cells to grow in size (a) extracellular signals that stimulate cell division. d) produced by mitotic cells to keep nearby neighboring cells from dividing 7.) Which of the following cyclins is most active during mitosis? (a) cyclin A (b) cyclin B (c) cyclin C (d) cyclin D 8) Which molecule inactivate itotic cyclin-CDK complexes using phosphorylation? (a) Cdc25 (b) Cdc6 (c) Weel (d) Helicase 9.) What...