What are the roles of the retinoblastoma protein (Rb)? a) it acts as a tumor suppressor...
What are the roles of the retinoblastoma protein (Rb)?
a) it acts as a tumor suppressor
b) it is an inhibitor of cell proliferation
c) it is a substrate for cyclin dependant kinases that inactivate Rb
d) all of the above
Homework Answers
Correct option: C. All of the above.
Rb acts as a tumor suppressor gene. The presence of un-phosphorylated active form of Rb inhibits cell cycle by preventing DNA replication. When a normal cell requires undergo cell division, Rb (as a substrate) is phosphorylated by cdk2 and thus inactivated. Inactivation of Rb through phosphorylation triggers the cells to enter cell cycle.
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What are the roles of the retinoblastoma protein (Rb)?
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