Which of the following is NOT true of the Rb protein? a. It inhibits gene expression...
Which of the following is NOT true of the Rb protein?
a. It inhibits gene expression by binding to a gene regulatory
protein.
b. In the absence of mitogen it promotes cell proliferation.
c. Its activity is controlled by phosphorylation.
d. It is a tumor suppressor protein.
e. None of the above (= all of the above are true).
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Which of the following is NOT true of the Rb protein?
a. It inhibits gene expression...
GENE EXPRESSION PROFILE A RELATIVE EXPRESSION CYCLIN D RB E2F Information for the following problem: •...
GENE EXPRESSION PROFILE A RELATIVE EXPRESSION CYCLIN D RB E2F Information for the following problem: • CYCLIN D inhibits RB • RB inhibits E2F • E2F increases mitosis 1. Is the pattern seen in gene expression profile A consistent with cancer progression? If so, explain why you have come to that conclusion 2. If consistent with cancer progression, indicate the probable gene that is mutated, and if this represents an oncogenic or tumor suppressor mutation. In your explanation, make sure...
What are the roles of the retinoblastoma protein (Rb)? a) it acts as a tumor suppressor...
What are the roles of the retinoblastoma protein (Rb)? a) it acts as a tumor suppressor b) it is an inhibitor of cell proliferation c) it is a substrate for cyclin dependant kinases that inactivate Rb d) all of the above
Below is a list of hypothetical genes with the indicated function. Which genes could be classified...
Below is a list of hypothetical genes with the indicated function. Which genes could be classified as a tumor suppressor? (a) Gene A: Promotes Apoptosis (b) Gene B: Inhibits Cell Cycle (c) Gene C: Promotes Cellular Differentiation (d) Gene D: Extends Chromosome Ends During Cell Division (e) Gene E: Promotes Angiogenesis (f) Gene F: Inhibits Angiogenesis
1.The KRAS gene encodes the KRAS protein which functions to promote cell growth and division. A...
1.The KRAS gene encodes the KRAS protein which functions to promote cell growth and division. A single base-pair deletion occurs in exon 4 of the KRAS gene that results in an early stop codon. This mutation results in an unregulated KRAS protein that always sends growth signals. What is a correct classification of the normal (wildtype) KRAS gene? A) A tumor suppressor gene B) An oncogene C) A tumor activating gene D) A DNA repair gene E) A proto-oncogene 2....
Which of the following is a false statements about tumor suppressor genes? Gene amplification (duplication) of...
Which of the following is a false statements about tumor suppressor genes? Gene amplification (duplication) of a tumor suppressor gene is less likely to result in cancer than gene amplification of a proto-onocogene. Individuals with a single normal copy of a tumor suppressor gene are more prone to cancer than those with two normal copies. Inactivation of tumor suppressor genes can lead to enhanced cell survival and cell proliferation. Epigenetic changes that silence tumor suppressor genes would not lead to...
1. Which of the following is a tumor suppressor gene (or the product of a tumor...
1. Which of the following is a tumor suppressor gene (or the product of a tumor suppressor gene)? Select all answers that apply. A. Raf B. Her2 receptor C. PTEN D. INK4a E. p53 2. Which of the following is a proto-oncogene (or the product of a proto-oncogene)? Select all answers that apply. A. APC B. EGFR C. bcl-2 D. RB E. ptc1
Please answer 2-5 2. Consider a gene with a particular function. Mutation X and mutation Y...
Please answer 2-5
2. Consider a gene with a particular function. Mutation X and mutation Y cach cause defects in the function of the encoded protein, yet a gene containing both mutations X and Y encodes a protein that works even better than the original protein. The odds are exceedingly small that a single mutational event will generate both mutations X and Y. Explain a simple way that an organism with a mutant gene containing both mutations X and Y...
A tumor suppressor gene is best described by which of the following? a. when it is...
A tumor suppressor gene is best described by which of the following? a. when it is expressed, the gene suppresses viral genes from being expressed b. a gain-of-function mutation lead to uncontrolled proliferation c. when it is express, the gene induces tumor formation d. a loss-of-function mutation leads to uncontrolled proliferation e. when it is expressed, the gene specifically blocks the G 1/S checkpoint.
4. (2pts) Which of the following is true concerning expression levels of the BIS gene in...
4. (2pts) Which of the following is true concerning expression levels of the BIS gene in cells expressing miR-5? BIS gene expression is increased in these cells BIS gene expression is decreased in these cells BIS gene expression remains unchanged in cells expressing miR-5 Transcription initiation of BIS is negatively regulated Question 4 2 pts 5.(2pts) Which of the following are true of p101 expression in these cells? o increased amounts of the p101 protein due to low levels of...
Retinoblastoma (resulting in eye tumor) results from inactivation of Rb gene, a tumor suppressor. A).List the molecular events that lead to the development of hereditary retinoblastoma? _____________...
Retinoblastoma (resulting in eye tumor) results from inactivation of Rb gene, a tumor suppressor. A).List the molecular events that lead to the development of hereditary retinoblastoma? ________________________________________________________________________________________________________________________________________________________________________________________________ B). How the development of sporadic retinoblastoma will be different from the hereditary one? Mention the molecular steps that will be unique for the sporadic retinoblastoma? _________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________ C). Is the loss of Rb function dominant or recessive and why? ________________________________________________________________________________________________________________________________________________________________________________________________ D). Knowing the Rb binds to E2F, which is transcription factor activating expression...
GENE EXPRESSION PROFILE A RELATIVE EXPRESSION CYCLIN D RB E2F Information for the following problem: • CYCLIN D inhibits RB • RB inhibits E2F • E2F increases mitosis 1. Is the pattern seen in gene expression profile A consistent with cancer progression? If so, explain why you have come to that conclusion 2. If consistent with cancer progression, indicate the probable gene that is mutated, and if this represents an oncogenic or tumor suppressor mutation. In your explanation, make sure...
Please answer 2-5
2. Consider a gene with a particular function. Mutation X and mutation Y cach cause defects in the function of the encoded protein, yet a gene containing both mutations X and Y encodes a protein that works even better than the original protein. The odds are exceedingly small that a single mutational event will generate both mutations X and Y. Explain a simple way that an organism with a mutant gene containing both mutations X and Y...
4. (2pts) Which of the following is true concerning expression levels of the BIS gene in cells expressing miR-5? BIS gene expression is increased in these cells BIS gene expression is decreased in these cells BIS gene expression remains unchanged in cells expressing miR-5 Transcription initiation of BIS is negatively regulated Question 4 2 pts 5.(2pts) Which of the following are true of p101 expression in these cells? o increased amounts of the p101 protein due to low levels of...
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