In treating a lactating febrile cow with mastitis, you have a choice of several antibiotic preparations to which the infecting bacteria is susceptible. Which IV drug from the choices below would be most effective based on the greatest milk to plasma ratio which you can produce? (assume milk pH = 6.4)
Acid drug, pKa = 8.4
Acid drug, pKa = 6.4.
Basic drug, pKa = 8.4
Basic drug, pKa = 7.4
Acid drug, pKa= 6.4, this is to produce maximum milk so that plasma ratio will be produced more effectively.
In treating a lactating febrile cow with mastitis, you have a choice of several antibiotic preparations...