Explain the molecular basis for the complications that arise from sickle-cell a (10 pts) nemia.
Thrombocytopenia symptoms, complications, and lab values Sickle cell anemia causes, symptoms .Hypotension patho (RAAS system) Ulcer types and locations; symptoms . Hepatitis types and transmissions
1. What is the cell and physiological basis for the protective effect of sickle cell against malaria? 2. How do hemoglobin molecules function (or malfunction) when they include two chains of HbS?
explain, in detail, the relationship between malaria and sickle-cell anemia. Why is having one sickle-cell allele considered a selective advantage? Is this equally beneficial for someone who is homozygous recessive for sickle-cell? Why or why not? Note: use specific vocabulary to describe your answers (genotype, homozygous d, homozygous r, natural selection, heterozygous, etc)
6. Sickle cell anemia (disease) is described as an autosomal recessive condition (individuals must have two copies of the recessive allele to display “sickle cell disease”). However, sickle cell trait (the heterozygous condition) has a unique phenotype. a. How would you classify/describe sickle cell trait at the organismal level (complete, incomplete, or co-dominance)? Explain your reasoning. b. How would you classify/describe sickle cell trait at the molecular level (complete, incomplete, or co-dominance)? Explain your reasoning. (HINT: think about the hemoglobin...
4. (10 pts) The family in the pedigree shown below are from an American Hispanic population, Individual II3 has sickle cell disease. a. What is the probability that the first offspring of individual II5 and II6 will have sickle cell disease? b. Explain to the couple how you arrived at this probability. ato ooo to
1. Explain how some patients who are homozygous for the sickle-cell allele do not develop sickle-cell crisis or other symptoms of the disease. Because of a mutation to a regulatory gene, a variant form of the beta subunit is expressed that does not cause sickling of hemoglobin protein. Because of a defective regulatory gene, fetal hemoglobin is expressed in adulthood which compensates for defective adult hemoglobin. Because of an additional mutation to the gene for the beta subunit of hemoglobin,...
0.5. What fraction of the offsprings of two parents with Sickle cell trait would you expect to have Sickle cell anemia? Q.6. List the major steps you undertake for performing ELISA? 0.7. Describe an ELISA procedure you'll undertake to determine if a person is infected with AIDS virus? Q.3. In the two protein gel electrophoresis labs done in this class, proteins were separated based on their net charge or their size (weight). Explain similarities and differences between these two laboratory...
Explain how the mutation would cause the clinical manifestations of sickle cell anemia?
A woman in a high risk population has the gene for sickle-cell is 1/10. If the woman has the gene each of her children has the probability 1/2 of having the disease, if she does not the probability is zero. If the woman has 3 sons without sickle-cell what is the probability that she carries the sickle-cell gene?
Explain how the allele that causes the fatal condition of sickle-cell anemia has been preserved in certain populations that are exposed to malaria. Why is sickle-cell anemia relatively frequent today even among populations who live in geographic regions where malaria is under control?