Complete the synthesis below. (3 pts.) OH 2 HB , hy CHO,BE 7. 1.0 equiv. TMSCI,...
4. Complete the reactions below by supplying the reactant, reagent or product. (*pts each OH b H,0,HCI Heat O it CI d. (excess) 1. LAIH 2. H2O -CHCH PPh; 3 Name: f. 1. CHACHIMBI 2. H,0 1. LAIH 2. HO h. CuLi(CH 3)2 i. 1. LDA (1 equiv) 2. CHỊCH,C 5
6. Provide structures of the products in the boxes (40 points) лон CHO 1 Li 2. Hy-Pa 2. H.O 1. HOCH,CH,OH, TOH(cat) 1. LAH 2. H,0 2. LAH 3. H,0 1. CH,MgBr 2. H,0 2.HO 1. SOCI 1.0 2. H,O, 2. CH,OH L. excess SOC Ag HCI 2. CH,OH, Heat
2. (3 pts) Consider the stereoisomers (A-E) drawn below. CHO CHO CHOCHO HCB BCHCOH HOCH HOCNH, HNC OH HANC Br BrCNH CH-OH CH OH CH,OH C D CHO CH,OH HNC OH CH-OH Which structure is an enantiomer of structure A? 3. (4 pts) Identify the chirality centers in the antibiotic ampicillin (shown below). Η
The following synthesis is done in 3 steps.
1. The selective oxidation of alcohols.
2. Aromatic Grignard
3. Carbon-Carbon coupling.
Perform stoichiometric calculations to obtain 1 ml of
the final product, using the concept of limit reagent in the
synthesis of geranial and phenylmagnesium bromide. assuming 100%
yield.
The complete equations of the synthesis of geranial and
grignard reagent are shown below. (They are needed to calculate the
final 1 ml of product of the reaction above)
Density of Final...
-NH2 PCC, CH2Cl2 NaBH CN OH 8 Br 1. 3 equiv. 12 4 equiv. NaOH 1. LiAlH4 2. H2O 2. H30* 9 10 2 equiv. (CH3)2NH 1. LiAIH 2. H20 11 12 H2O 1. CH,MgCI 2. H30 13 14
4. (3 pt) Which synthesis below would work best for the following transformation? OH A. 1. Mg in ether, 2. CH CHO with an H+ workup B. 1. MeLi, 2. CH CHO with an H+ workup C. NaOMe and heat D. NaBH, then H+ workup
15. HN оо CO; 1) (CH3)3COCOCOC(CH3)3 2) -N:CENH CHO HOTH PhNHNH | 16. HOH (3 equiv.) HO+H н+он CH OH 17. Use ANY needed reagents to effect the following transformation. (30 points) starting material product
15. HN оо CO; 1) (CH3)3COCOCOC(CH3)3 2) -N:CENH CHO HOTH PhNHNH | 16. HOH (3 equiv.) HO+H н+он CH OH 17. Use ANY needed reagents to effect the following transformation. (30 points) starting material product
Could you please answer questions 2-5
2. Complete the following reactions by writing the missing reagents or products (8 points) CrO; но" PBry CH,CH,CH.CH.CH-OH 3. Find the best synthetic method for the following coverstion (8 points) (CHCHCH OH CH),CHCH,BE - S (CH, CHCH MgBr (CHỊ) CHCHACH-CO-H (CH),CHCH.CH.CH OH 4. Draw a multistep synthetic route to accomplish the following transformation (8 points) 3. Draw the structure of the starting material that would be needed in the following reactions (8 points) HOCH...
What are the best reagents to complete this synthesis? O 1. BH3 – THF; 2. H2O2, NaOH; 3. PCC O 1. BHz – THF; 2. H2O2, NaOH; 3. H, CrO4 01. 03; 2. DMS 01. Hg(OAC)2, H2O; 2. NaBH4; 3. PCC Predict the product of the following reaction scheme: 2LIATH H2O OH OH Predict the product for the following reaction | | Identify the reaction sequence of reactions that can achieve the following transformation a- O (1) Br2, CCl4: (2)...