Question

A particular peptide has a stop-transfer sequence in the middle regions of its sequence. The stop- transfer sequence is surrounded by hydrophilic regions on either side and the amino terminal of the peptide contains a few asparagine residues. Describe the orientation of the peptide in the ER membrane. The asparagines and the C-terminal faces the ER lumen The asparagines and the C-terminal faces the cytoplasm The asparagines face the ER lumen, the C-terminal faces the cytoplasm The asparagines face the cytoplasm, the C-terminal faces the ER lumen

Answer 1

Ans- d. the asparagines face the cytoplasm, the C-terminal faces ER lumen.

Explanation- Because of the presence of asparagine at N-terminal, the N-terminal will face cytoplasm and C-terminal will lie in ER lumen.