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Explain the role of BPG in Hb function. How is BPG involved with adaptation to high altitude? Draw and label a graph that illustrates Hb at low and high altitude. (10 pts.) WI
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Ans) BPG is the short name of 2,3-bisphosphoglycerate. This compound is formed from 1,3-bisphosphoglycerate, which is an intermediate of glycolysis. When 1,3-BISPHOSPHOGLYCERATE accumulates in blood, it gets converted into BPG.

One molecule of BPG binds to tetramer hemoglobin in T form. It stabilizes, thereby, the deoxygenated form of hemoglobin. The increased concentration of BPG the affinity of hemoglobin for oxygen.

At high altitude, partial pressure of oxygen is low. So, body requires more oxygen to fulfill his needs. For this some adaptations are needed at high altitude. For example, respiratory rate increases and erythrocyte number increases. Also BPG facilitates the release of oxygen in tissues from hemoglobin by lowering the affinity of hemoglobin for oxygen in tissues.

Diagram is as follows :

Pago Dato Effect of , 3 PP 1o0 2.

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