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#1. What is calcineurin? Compare its method of activation and signaling of downstream targets with that...

#1. What is calcineurin? Compare its method of activation and signaling of downstream targets with that of the insulin receptor in table format. What is a disease associated with it and a drug that can be used to block its activity.

#2. What is the Philadelphia chromosome and the disease associated with it? Explain the signaling mechanism of the 2 genes when fused. What is TASIGNA and how can it be used as a specific pharmaceutical for treatment?

#3. What are SERMs? Explain their target and mode of action. What concerns are there in the use of SERMs.What are SERDs and how do they compare to SERMs?

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DATE alchnewinis acalciuma and Calmodulin dopen lont s thteonine hown as onse acivu mecro and tacralimu lasmie Achisahons ans

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