Question

Activating/Deactivating Substituents Below is a list of different substituents and experimental results from attempted electrophilic aromatic substitution. PhNR, PHCN PhCHO PhF PhMe PhoMe PhNH Deactivating Activating PhNO, PhSozH Phl PhH PNHAC POH • Is the aromatic ring an [ electrophile / nucleophile ] in these reactions? Which substituents 'activate the ring (i.e. make it more reactive? 0 Alkyl substituents: Activate OR Deactivate o Halide substituents: Activate OR Deactivate o OH, NH substituents: Activate OR Deactivate o carbonyl groups: Activate OR Deactivate o Nitro groups: Activate OR Deactivate

Answer 1

• Aromatic ring » A nucleophele o Alkyl substituents : Activate O Halede substituents : deactivate o OH, NH substituents: Activate o carbonyl groups : Deactivate Nitro groups: Deactivate 0 - м қатттех, the atom next to the o substituents curéth a lone pour m ring: Activate atom next to the o substituent, with a T bond on the - ring! Activate through induced • Alkyl groups are dipoles which: electron donating Activate HS o (majer) FC-F Crocod Akela © (major) OH (CH3)2 CH CH 4 - Alch (magos) COH CH₂ CH (erba

CH₂ OK CH₂on 5 он, де “NO, mech: | црн, H CHOK ) осHд