The first step in the metabolic breakdown of glucose is its phosphorylation to G6P:
glucose(aq)+ATP(aq)→G6P(aq)+ADP(aq)+H+(aq)glucose(aq)+ATP(aq)→G6P(aq)+ADP(aq)+H+(aq)
The standard reaction Gibbs energy for the reaction isΔGoΔGo= -34 kJ/mol at 37°C
A.
Calculate the biological standard reaction GIbbs energy for the reaction at 37°C.
B. Calculate the equilibrium constant of the reaction in the thermodynamic standard (KeqKeq) at 37°C. Use 2 significant figures.
c, Calculate the equilibrium constant of the reaction in the biological standard (K′eqKeq′) at 37°C. Use 2 significant figures.
The first step in the metabolic breakdown of glucose is its phosphorylation to G6P: glucose(aq)+ATP(aq)→G6P(aq)+ADP(aq)+H+(aq)glucose(aq)+ATP(aq)→G6P(aq)+ADP(aq)+H+(aq) The...
The first step in the metabolic breakdown of glucose is its phosphorylation to G6P: glucose(aq) + ATPlaq)→G6P(aq) + ADP(aq) + H+ (aq) The standard reaction Gibbs energy for the reaction is AG -34 kJ/mol at 37°C ▼ Part A Calculate the biological standard reaction Glbbs energy for the reaction at 37 C AG68.0 kJ/mol Submit Previous Answers Request Answer X Incorrect; Try Again; 2 attempts remaining Part B Calculate the equilibrium constant of the reaction in the thermodynamic standard (Kea)...
Consider the hydrolysis of ATP: ATP(aq) + H2O(l) → ADP(aq) + Pi(aq). This reaction has ΔH°= −24.3 kJ/mol and ΔS°= +21.6 J/mol-K. The actual concentrations of ATP, ADP, and Pi are not 1 M in a biological cell. How much energy can the conversion of ATP to ADP supply when it occurs at physiological conditions in E. coli where the temperature is 37°C and the approximate concentrations are ATP = 11.2 mM, ADP = 1.52 mM, Pi = 20.0 mM?...
Question 11 1 pts Consider the hydrolysis of ATP: ATP(aq) + H2O(1) - ADP(aq) + P(aq). This reaction has AH°= -24.3 kJ/mol and AS - +21.6 J/mol-K. The actual concentrations of ATP, ADP, and Pi are not 1 Min a biological cell. How much energy can the conversion of ATP to ADP supply when it occurs at physiological conditions in E.coli where the temperature is 37°C and the approximate concentrations are ATP - 14.8 mM, ADP - 3.65 MM, P,...
CHEM 351 Biochemistry I - Fall 2018 Study Problems for Metabolism and Glucose Catabolism For the reaction: aA + bB =cC + dD Gibbs free energy: AG = AG" + RT IN THE glucose + glucose 6-phosphate + H20 1. The equilibrium constant for phosphorylation of glucose is: Ke = 3.97 x 10- a. Calculate the standard Gibbs free energy for the uncatalyzed reaction. b. Use the physiological concentrations for glucose (2.0 mm) and inorganic phosphate (20 mM) to determine...
The concentration of fructose 6-phosphate (F6P) and fructose 1, 6-biphosphate (F16BP), ATP, and ADP in muscle tissue were measured as 0.089, 0.012, 12.0, and 1.2 mM. For the reaction F6P(aq) + ATP(aq) rightarrow F16BP(aq) + ADP(aq) at 37 degree C, the standard Gibbs energy (at pFl=7) is -18.3 kJ/mol. Calculate the reaction Gibbs energy (kJ/mol) for the reaction in the muscle tissue environment. -71.2 -29.4 -7.3 +4.5 +11.2.
The enzyme hexokinase catalyzes the following reaction: Glucose + ATP ↔ Glucose 6-phosphate + ADP For this reaction, ΔG° = +16.7 kJ/mol a. Calculate the equilibrium constant for this reaction at 25 °C. Is this reaction spontaneous under standard conditions at this temperature? Calculate the ΔG if the reaction temperature was 25 °C and the concentrations are: glucose, 55.0 mM,; ATP, 5.00 mM; ADP, 1.00 mM; and glucose 6-Phosphate, 0.100 mM. Would the reaction be spontaneous under the conditions of...
Hexokinase catalyzes the following reaction in glycolysis: Glucose + ATP ← → glucose-6-phosphate + ADP The standard free-energy change for this reaction in the direction written is -16.7 kJ/mol. The concentrations of the related reaction components in the hepatocyte of a mammalian cell are: Glucose: 6 mM Glucose-6-phosphate: 0.074 mM ATP: 1.00 mM ADP: 0.25 mM What is the actual free-energy change for the reaction at body temperature (37 C)?
The first reaction in glycolysis is the phosphorylation of glucose:Pi+glucose⟶glucose−6−phosphate+H2OThis is a thermodynamically unfavorable process, with ΔG∘′=+13.8kJ/mol.Part AIn a liver cell at 37 ∘C the concentrations of both phosphate and glucose are normally maintained at about 5 mM each. =>theequilibrium concentration of glucose-6-phosphate = 1.2*10^-7 MPart BThis very low concentration of the desired product would be unfavorable for glycolysis. In fact, the reaction is coupled to ATP hydrolysis to give the overall reactionATP+glucose⟶glucose−6−phosphate+ADP+H+ΔG∘′ for the coupled reaction is -18.4 kJ/mol
2. The first step in glycolysis is catalyzed by the enzyme herokinase: glucose + ATP glucose-6-P + ADP This reaction can be thought of as two coupled reactions (P is phosphate): (1) glucose + P + glucose-6-P (2) ATP + ADP + P For the overall reaction, AG" = -16.7 kJ/mol. For the hydrolysis of ATP (equation 2), AG = -310 kJ/mol. All reactions are performed at 37°C. (a) What is AGº for reaction 1? Iglucose - 6-11 if AG...
Adenosine triphophste, ATP, is used to store energy within biological systems. It releases that energy by losing a terminal phosphate group, Pi, to form adenosine diphophate, ADP, through the hydrolysis reaction. The standard reaction Gibbs energy for hydrolysis of ATP to ADP is + 10 kJ mol at 298K. This assumes that the concentration of hydrogen ions is 1 mol/ L. a) In biochemistry, it is common practice to assume an alternative, and more realistic, standard state for pH=7. What...