Hexokinase catalyzes the following reaction in glycolysis: Glucose + ATP ← → glucose-6-phosphate + ADP The...
Hexokinase catalyzes the following reaction in glycolysis:
Glucose + ATP ← → glucose-6-phosphate + ADP
The standard free-energy change for this reaction in the
direction written is -16.7 kJ/mol.
The concentrations of the related reaction components in the
hepatocyte of a mammalian cell are:
Glucose: 6 mM
Glucose-6-phosphate: 0.074 mM
ATP: 1.00 mM
ADP: 0.25 mM
What is the actual free-energy change for the reaction at body temperature (37 C)?
Homework Answers
Free-energy change of a reaction depends on the concentration of the reactants and products and the temperature at which the reaction takes place. It is given by the equation:
ΔG = ΔG0 + RT ln Q
where ΔG0 is the standard free-energy change for this reaction, and Q is the reaction quotient
Here, ΔG0 = -16.7 kJ/mol and Q = (0.074 mM * 0.25 mM) / (6 mM * 1 mM) with T = 310 K
On calculating, we get ΔG = -31.60 kJ/mol
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Hexokinase catalyzes the following reaction in glycolysis:
Glucose + ATP ← → glucose-6-phosphate + ADP
The...
The enzyme hexokinase catalyzes the following reaction: Glucose + ATP ↔ Glucose 6-phosphate + ADP For...
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QUESTION 12 A eukaryotic cell can use glucose (C6H1206) and hexanoic acid (C6H1402) as fuels for...
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7.5 Hexokinase catalyzes the reaction: ATP + Glucose A glucose-6-phosphate + ADP AG - -4 562...
7.5 Hexokinase catalyzes the reaction: ATP + Glucose A glucose-6-phosphate + ADP AG - -4 562 cal / mol Keg = 2.21 x 103 Calculate the concentration of glucose-6-phosphate necessary to force the hexokinase reaction to go in the opposite direction (towards the synthesis of glucose and ATP) in the presence of 10-5 M glucose, 10-3 M ATP and 10-4 M ADP.
Hexokinase catalyzes the first step of glycolysis, in which glucose is phosphorylated to form glucose-6-phosphate. Which...
Hexokinase catalyzes the first step of glycolysis, in which glucose is phosphorylated to form glucose-6-phosphate. Which of these statements are accurate? The conformational shift that occurs when glucose, but nox water, enters the active site prevents water from hydrolyzing ATP Most kinases require the presence of a monovalent metal ion cofactor to prevent ATP hydrolysis. Hexokinase transfers the terminal phosphate of ATP to carbon 3 of glucose. Hexokinase consists of two domains, or lobes, that come together when glucose and...
1. Hexokinase catalyzes the ATP-dependent phosphorylation of a broad spectrum of 6- carbon sugars. In the...
1. Hexokinase catalyzes the ATP-dependent phosphorylation of a broad spectrum of 6- carbon sugars. In the reaction involving glucose and ATP, glucose-6-phosphate (G6P) and ADP are formed. D-Glucose + ATP G6P + ADP + Ht (AG",--20.9 kJ/mol). The enzyme specifically recognizes the acetal form of glucose, (a-D-glucopyranose. a. Draw the linear form of glucose using a Fischer projection and draw the structure of (a-D-glucopyranose. (5 pts each) b. Provide the net reaction for glycolysis. (5 pts) c. Assuming lysine acts...
2. The first step in glycolysis is catalyzed by the enzyme herokinase: glucose + ATP glucose-6-P...
2. The first step in glycolysis is catalyzed by the enzyme herokinase: glucose + ATP glucose-6-P + ADP This reaction can be thought of as two coupled reactions (P is phosphate): (1) glucose + P + glucose-6-P (2) ATP + ADP + P For the overall reaction, AG" = -16.7 kJ/mol. For the hydrolysis of ATP (equation 2), AG = -310 kJ/mol. All reactions are performed at 37°C. (a) What is AGº for reaction 1? Iglucose - 6-11 if AG...
The first reaction in glycolysis is the phosphorylation of glucose:
The first reaction in glycolysis is the phosphorylation of glucose:Pi+glucose⟶glucose−6−phosphate+H2OThis is a thermodynamically unfavorable process, with ΔG∘′=+13.8kJ/mol.Part AIn a liver cell at 37 ∘C the concentrations of both phosphate and glucose are normally maintained at about 5 mM each. =>theequilibrium concentration of glucose-6-phosphate = 1.2*10^-7 MPart BThis very low concentration of the desired product would be unfavorable for glycolysis. In fact, the reaction is coupled to ATP hydrolysis to give the overall reactionATP+glucose⟶glucose−6−phosphate+ADP+H+ΔG∘′ for the coupled reaction is -18.4 kJ/mol
Consider the following reaction: Glucose + ATP ↔Glucose -6-phosphate + ADP Using the information in the...
Consider the following reaction:
Glucose + ATP ↔Glucose -6-phosphate + ADP
Using the information in the below determine Go for
this reaction and comment on the spontaneity of this reaction.
What the information does the Go parameters in the
table below provides about the rate of the ATP hydrolysis.
Below is the structure of glucose-6-phosphate. Identify which
anomer does it represent?
Standard free energies of hydrolysis of some
phosphorylated compounds
compound
Go (kJ mol-1)
ATP (to ADP)
-30.5
pyrophosphate
-19.3...
the enzyme hexokinase can catalyze the following reaction: fructose + ATP -> fructose 6 phosphate +...
the enzyme hexokinase can catalyze the following
reaction:
fructose + ATP -> fructose 6 phosphate + adp
if the deltaG of hydrolysis of fructose 6 phosphate to
fructose + Pi is -13.8 kj/mol and hydrolysis of atp to adp + pi is
-30kj/mol, calculate Keq for the reaction above (R = 8.31 j mol-1
K-1, T = 298 k
3a. The enzyme hexokinase can catalyze the following reaction: Fructose + ATP → Fructose-6-phosphate + ADP If the ΔGo of hydrolysis...
Question 1 1 pts The enzyme hexokinase transfers a phosphate from ATP to glucose, to make...
Question 1 1 pts The enzyme hexokinase transfers a phosphate from ATP to glucose, to make ADP and glucose-6- phosphate. Which of the following is a substrate? hexokinase ADP glucose glucose-6-phosphate two of the above Question 2 1 pts The enzyme hexokinase transfers a phosphate from ATP to glucose, to make ADP and glucose-6- phosphate. Which of the following is a product? hexokinase ADP glucose glucose-6-phosphate two of the above
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Hexokinase catalyzes the first step of glycolysis, in which glucose is phosphorylated to form glucose-6-phosphate. Which of these statements are accurate? The conformational shift that occurs when glucose, but nox water, enters the active site prevents water from hydrolyzing ATP Most kinases require the presence of a monovalent metal ion cofactor to prevent ATP hydrolysis. Hexokinase transfers the terminal phosphate of ATP to carbon 3 of glucose. Hexokinase consists of two domains, or lobes, that come together when glucose and...
1. Hexokinase catalyzes the ATP-dependent phosphorylation of a broad spectrum of 6- carbon sugars. In the reaction involving glucose and ATP, glucose-6-phosphate (G6P) and ADP are formed. D-Glucose + ATP G6P + ADP + Ht (AG",--20.9 kJ/mol). The enzyme specifically recognizes the acetal form of glucose, (a-D-glucopyranose. a. Draw the linear form of glucose using a Fischer projection and draw the structure of (a-D-glucopyranose. (5 pts each) b. Provide the net reaction for glycolysis. (5 pts) c. Assuming lysine acts...
2. The first step in glycolysis is catalyzed by the enzyme herokinase: glucose + ATP glucose-6-P + ADP This reaction can be thought of as two coupled reactions (P is phosphate): (1) glucose + P + glucose-6-P (2) ATP + ADP + P For the overall reaction, AG" = -16.7 kJ/mol. For the hydrolysis of ATP (equation 2), AG = -310 kJ/mol. All reactions are performed at 37°C. (a) What is AGº for reaction 1? Iglucose - 6-11 if AG...
Consider the following reaction:
Glucose + ATP ↔Glucose -6-phosphate + ADP
Using the information in the below determine Go for
this reaction and comment on the spontaneity of this reaction.
What the information does the Go parameters in the
table below provides about the rate of the ATP hydrolysis.
Below is the structure of glucose-6-phosphate. Identify which
anomer does it represent?
Standard free energies of hydrolysis of some
phosphorylated compounds
compound
Go (kJ mol-1)
ATP (to ADP)
-30.5
pyrophosphate
-19.3...
the enzyme hexokinase can catalyze the following
reaction:
fructose + ATP -> fructose 6 phosphate + adp
if the deltaG of hydrolysis of fructose 6 phosphate to
fructose + Pi is -13.8 kj/mol and hydrolysis of atp to adp + pi is
-30kj/mol, calculate Keq for the reaction above (R = 8.31 j mol-1
K-1, T = 298 k
3a. The enzyme hexokinase can catalyze the following reaction: Fructose + ATP → Fructose-6-phosphate + ADP If the ΔGo of hydrolysis...
Question 1 1 pts The enzyme hexokinase transfers a phosphate from ATP to glucose, to make ADP and glucose-6- phosphate. Which of the following is a substrate? hexokinase ADP glucose glucose-6-phosphate two of the above Question 2 1 pts The enzyme hexokinase transfers a phosphate from ATP to glucose, to make ADP and glucose-6- phosphate. Which of the following is a product? hexokinase ADP glucose glucose-6-phosphate two of the above
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