Question

1. Hexokinase catalyzes the ATP-dependent phosphorylation of a broad spectrum of 6- carbon sugars. In the reaction involving glucose and ATP, glucose-6-phosphate (G6P) and ADP are formed. D-Glucose + ATP G6P + ADP + Ht (AG,--20.9 kJ/mol). The enzyme specifically recognizes the acetal form of glucose, (a-D-glucopyranose. a. Draw the linear form of glucose using a Fischer projection and draw the structure of (a-D-glucopyranose. (5 pts each) b. Provide the net reaction for glycolysis. (5 pts) c. Assuming lysine acts as a general base to produce an oxyanion nucleophile, provide a mechanism for the ATP-dependent phosphorylation of glucose as catalyzed by hexokinase. (10 pts)
0 0
Add a comment Improve this question Transcribed image text
Answer #1

OH Hーと 2 Lipear, Open chaw struckua The name o- artises fromthe axial position Harev chon arisit ruaspect The net reati Grlutase net into tuo moteculs Pyruic A DP to AT? nd yuvie aud and with the cerveagam δ 1a abase t le an NH Ho lonepaur takes op itu alcholie pretey This oxyanion act o nudeopkuli and attack to the rhosphous atoxm ATP molecute NH Eilupce6 phosphe (et6P)Thank you

Add a comment
Know the answer?
Add Answer to:
1. Hexokinase catalyzes the ATP-dependent phosphorylation of a broad spectrum of 6- carbon sugars. In the...
Your Answer:

Post as a guest

Your Name:

What's your source?

Earn Coins

Coins can be redeemed for fabulous gifts.

Not the answer you're looking for? Ask your own homework help question. Our experts will answer your question WITHIN MINUTES for Free.
Similar Homework Help Questions
  • Hexokinase catalyzes the following reaction in glycolysis: Glucose + ATP ← → glucose-6-phosphate + ADP The...

    Hexokinase catalyzes the following reaction in glycolysis: Glucose + ATP ← → glucose-6-phosphate + ADP The standard free-energy change for this reaction in the direction written is -16.7 kJ/mol. The concentrations of the related reaction components in the hepatocyte of a mammalian cell are: Glucose: 6 mM Glucose-6-phosphate: 0.074 mM ATP: 1.00 mM ADP: 0.25 mM What is the actual free-energy change for the reaction at body temperature (37 C)?

  • 7.5 Hexokinase catalyzes the reaction: ATP + Glucose A glucose-6-phosphate + ADP AG - -4 562...

    7.5 Hexokinase catalyzes the reaction: ATP + Glucose A glucose-6-phosphate + ADP AG - -4 562 cal / mol Keg = 2.21 x 103 Calculate the concentration of glucose-6-phosphate necessary to force the hexokinase reaction to go in the opposite direction (towards the synthesis of glucose and ATP) in the presence of 10-5 M glucose, 10-3 M ATP and 10-4 M ADP.

  • The enzyme hexokinase catalyzes the following reaction: Glucose + ATP ↔ Glucose 6-phosphate + ADP For...

    The enzyme hexokinase catalyzes the following reaction: Glucose + ATP ↔ Glucose 6-phosphate + ADP For this reaction, ΔG° = +16.7 kJ/mol a. Calculate the equilibrium constant for this reaction at 25 °C. Is this reaction spontaneous under standard conditions at this temperature? Calculate the ΔG if the reaction temperature was 25 °C and the concentrations are: glucose, 55.0 mM,; ATP, 5.00 mM; ADP, 1.00 mM; and glucose 6-Phosphate, 0.100 mM. Would the reaction be spontaneous under the conditions of...

  • 1. When the cell’s ATP supply is depleted, which of the following enzyme’s activity is increased?...

    1. When the cell’s ATP supply is depleted, which of the following enzyme’s activity is increased? Hexokinase Pyruvate kinase Glucokinase Phosphofructokinase Explain why this enzyme activity is tied to ATP levels. 2. The pyruvate kinase catalyzed step is not a reversible reaction in glycolysis, how then does gluconeogenesis start from pyruvate? Show the mechanism of the first step of gluconeogenesis. 3. Which of the following cofactors do not form a covalent bond with enzymes' lysine residues? Lipoamide Biotin NADH Pyridoxyl...

  • 6) What is one of the primary functions of oxidative phosphorylation? a) To capture chemical energy...

    6) What is one of the primary functions of oxidative phosphorylation? a) To capture chemical energy by converting ADP into ATP (phosphorylation). b) To oxidize H2O to O2 under anaerobic conditions c) To convert fructose to fructose-6-phosphate. d) To convert glucose-6-phosphate to fructose-6-phosphate. e) To create a buffer to keep the blood pH at 7.4 7) Monosaccharides are linked in polysaccharides through "glycosidie linkages". Structurally, a glycosidic linkage is ... a) an ester b ) an amide c) a thioester...

  • What is the correct answer? And please explain in 2-3 sentences on why it is the...

    What is the correct answer? And please explain in 2-3 sentences on why it is the correct answer for each, thank you ! 15. Which statement below about the interconversion of the alpha and beta anomers of D-glucopyranose is true? The interconversion requires an enzyme called an isomerase The interconversion is spontaneous in water because the acetal functionality is labile The interconversion is spontaneous in water but is slow which is why we typically draw glucose having one anomeric form...

  • this are very difficult questions for my environmental biology class. These are examples from the practice...

    this are very difficult questions for my environmental biology class. These are examples from the practice homework so can anyone please help me check my answers. -) The temperature classes of microorganisms are based on optimum temperatures of microbi A) cell wall C) cell membrane B) enzymes D) All of the above 20) Aerobic respiration, anaerobic respiration, and fermentation are all pathways of which involve the of nutrients. A) Catabolism, reduction B) Anabolism; oxidation C) Catabolism; oxidation D) Anabolism, reduction...

  • Page 5 SONDE BI.A fe The Add 45. ATP the following 9: 2 grup hete) of...

    Page 5 SONDE BI.A fe The Add 45. ATP the following 9: 2 grup hete) of the above The removal of t h e ATP in the production of energ 47. In Photophosphorylation, ATP ma n g theory of t. Ter! 48. The Phimaychain of www . d o rds through the force pro What is the one of these proce ? 4 Ke s Respiratory Chan Thangor A G W ok Regatory Chantren Thangar 6 Ragnary Chain Mangart Ghost...

  • 1. According to the paper, what does lactate dehydrogenase (LDH) do and what does it allow...

    1. According to the paper, what does lactate dehydrogenase (LDH) do and what does it allow to happen within the myofiber? (5 points) 2. According to the paper, what is the major disadvantage of relying on glycolysis during high-intensity exercise? (5 points) 3. Using Figure 1 in the paper, briefly describe the different sources of ATP production at 50% versus 90% AND explain whether you believe this depiction of ATP production applies to a Type IIX myofiber in a human....

ADVERTISEMENT
Free Homework Help App
Download From Google Play
Scan Your Homework
to Get Instant Free Answers
Need Online Homework Help?
Ask a Question
Get Answers For Free
Most questions answered within 3 hours.
ADVERTISEMENT
ADVERTISEMENT
ADVERTISEMENT