Question

< Question 5 of 15 > What is the general sequence of membrane trafficking for an extracellular protein? O endoplasmic reticulum, trans Golgi, secretory vesicle, cis Golgi, secretion from cell O Golgi apparatus, endoplasmic reticulum, secretory vesicle, secretion from cell O adoplasmic reticulum, cis Golgi, trans Golgi, secretory vesicle, secretion from cell O endoplasmic reticulum, Golgi apparatus, endosome, secretory vesicle, secretion from cell

Answer 1

Answer

Endoplasmic reticulum, cis Golgi, trans Golgi, secretory vesicle, secretion from cell

Two major cellular pathways shuttle material outward and inward. In the exocytic pathway, proteins synthesized in the cytoplasm are translocated into the endoplasmic reticulum (ER). Rough ER is the site of synthesis of all secreted proteins, and resident proteins for all compartments connected by vesicular transport. The ER is also the site where synthesis of most of the lipids in the cells begins. From the ER, membranous vesicles shuttle cargo to the Golgi apparatus. ER-derived cargo enters the Golgi in its cis cisterna, and moves through the medial and trans cisternae. In the trans Golgi, proteins destined for secretion or to be presented on the PM are packed into secretory vesicles that subsequently fuse with the PM. This fusion occurs either constitutively or, as in the case of regulated secretion, in response to an external signal. The Golgi apparatus is the major sorting compartment of the cell because in the Golgi cargo is sorted not only to the PM for constitutive and regulated secretion, but also to endosomes and lysosomes, or back to the ER