Question

Drag the terms on the left to the appropriate blanks on the right to complete the sentences. Terms can be used once, more than once, or not at all. Reset Help transport vesicle(s) Soon after initiation of translation of an mRNA coding for a secretory protein, the of the secretory protein is synthesized and is exposed on the surface of the ribosome. The signal recognition particle (SRP) contains the that marks this protein for into the endoplasmic reticulum cotranslational translocation (ER). The binds to the signal sequence and the ribosome and halts further translation carbohydrate The SRP/ribosome/mRNA complex binds to the ER membrane, with binding to its amino terminus receptor and the ribosome binding to a is released, translation signal peptidase resumes, and the growing polypeptide is extruded through the ER. In the lumen of the ER, the is cleaved by into the lumen of the and the protein is signal sequence glycosylated, folded with the help of , and packaged into a destined for chaperones the Golgi apparatus. The on the protein is modified as the protein passes through the protein translocation channel compartments of the Golgi, and the protein is packaged into destined for transport to the plasma membrane. Fusion of the membrane with the plasma membrane releases the secretory protein into the extracellular fluid.

Answer 1

The answer is written according to the blanks in order from beginning to end. Please follow and fill up in space:

signal sequence

amino terminus

signal sequence

cotranslational translocation

signal recognition particle (SRP)

signal recognition particle (SRP)

protein translocation channel

signal recognition particle (SRP)

protein translocation channel

signal sequence

signal peptidase

chaperones

transport vesicle(s)

carbohydrate

transport vesicle(s)

transport vesicle(s)