Using these types of genetic changes: Base substitution, Transition, Transversion, Missense mutation, Nonsense mutation, Insertion, Deletion, Frameshift mutation
Label these genetic changes (a-e). More than one answer may apply to each answer.
a. GC->CG in the protein coding region on a gene.
b. GC->TA in a GAA glutamate codon
c. Loss of three bases GAA for a glutamate codon
d. GC->CG in a tRNA gene
e. GC->AT in the ribosome binding site of a mRNA
1 ..Base substitution means
The one amino acid base is substituted by another like A to G , C to A etc
It may cause 3 changes
Protein sequence may change eg in sickle cell anemia
Code is changed but while encording it the protein remain same is silent mutation
Change in codon may lead to sequence of stop codon so the new protein synthesis stops
2. Insertion
Means new base pair is added in it
Eg AAACTCGGG in 3' now become AAACCCTGGG
3.Deletion means
One base pair or sequence is deleted
AAACCGGG from above main sequence one C deleted
4 Frameshift means
Caused by insertion or deletion may cause change in reading codon
5. Nonsense mutation
Convert one base sequence into one of the three non sense codon
6. Missense mutation
Codon changes its sequence so diff amino acid sequence is produced
7 Transition means
Purine base pair replace purine and pyrimidine replace pyrimidine
8 transversion
Purine replaced by pyrimidine and vice versa
Purine is adenine and guanine
Pyrimidine is thymine and cytosine
Uracil in place of thymine in RNA
Answer
1 GC to CG Transversion
2 GC to TA Transversion
3 Deletion
4 GC to CG Transversion
5 GC to AT Transition
Using these types of genetic changes: Base substitution, Transition, Transversion, Missense mutation, Nonsense mutation, Insertion, Deletion,...
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11. Match each type of mutation with the corresponding description. (4 points) Missense An insertion or deletion of nucleotides that are not in multiples of 3. Nonsense A mutation that does not alter the protein sequence. Silent A mutation that confers an amino acid substitution. Frameshift A mutation that confers a premature stop codon.
Match each mutation with its appropriate description. A mutation that changes a codon that specifies an amino acid to a stop codon, resulting in premature termination of polypeptide synthesis. Silent mutation Frameshift mutation A mutation that results in a change in a codon such that a different amino acid is specified es Missense mutation A mutation that changes one codon to a different codon that specifies the same amino acid, such that there is no change in the resulting polypeptide....
A single mutation has occurred in the following DNA sequence. 5' ATG TTG GCC CAT 3' wild-type (normal) sequence 5' ATG TTG CCC CAT 3' mutant sequence (a) Identify and classify the mutation according to its molecular structure (i.e., insertion, deletion base substitution (transversion), or base substitution (transition)). Briefly explain why you selected this classification. (1.75 marks) (b) Identify and classify the mutation according to its functional effects (i.e., frameshift, missense, nonsense, or silent). Briefly explain why you...
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