Question

Linkage Disequilibrium

Mention one possible reason for why the level of LD in human populations is higher in Europe than in Africa?

Mention one possible reason to why the level of LD is higher in dogs than in e.g. humans?

Calculate LD between two biallelic loci in a situation where one haplotype is deleterious whereas the other haplotypes occur at equal frequencies.

After how many generations have the LD between two loci with a recombination rate of 0.1 declined to 50% of the starting LD?

Answer 1

Linkage disequilibrium deins feasibility of the study.

The level of LD in human populations is higher in Europe than in Africa due to SNPs that are absent in Europe , reflecting positive selection in West Africa. Africans have got dense SNPs.

The level of LD in dogs are higher than in humans because dogs have low haplotype diversity as well high degree of haplotype sharing among different breeds compairing to humans.

LD between two biallelic loci in the given situation,

r2 = (1- Pa) Pb / (1 - Pb) Pa