Question

(I only need the answer for #2)

High-throughput (next-generation) sequencing techniques are making ‘community genet- ics’ programmes more widely applicable, because cheap tests can be used to screen population members for asymptomatic heterozygote carriers of many different disease alleles.

1- What are the potential benefits and costs of this community genetics approach?

2- Give at least 3 benefits ( pros) and 3 costs (cons) ?

Answer 1

PROS AND CONS

PROS	CONS
Considering earlier Sanger sequencing,based on the separation by electrophoretic technique of chain-termination products obtained by individual sequencing reactions, next-generation sequencing involves the enormously parallel sequencing of single-DNA or clonally-amplified molecules that are spatially separated on a flow cell.	In case of determination of the causal mutations in the genetic disease, the difficulty in ascertaining the likely functional effects of deviations in non-coding parts of the genome is gargantuan.
Sequencing is done by repeated cycles of polymerase-mediated nucleotide extensions. As an enormously  parallel process, Next generation sequencing produce hundreds of gigabases of nucleotide-sequence output in a single run of instrument and has the capacity to sequence the complete genome in days to weeks.	Only 1% of the genome, the exome can be sequenced at a much less cost and in a snap of time,still generating sequence data for those desired areas as a causal mutation is most likely to be found.
Talking about the advanced technique next generation sequencing ,it is reliable,perform a faster analysis and generates accurate results.	Low yield of high quality sequence(high rate of sequencing error),though the equipment is expensive