Question

not sure if i did this right. please help.

1. Phenylketonuria (PKU) is a human metabolic disorder in whic allele a, lack a liver enzyme required for the breakdown of excess phens intellectual disabilities, delayed development, behavioral an problems. Men and women have an equal chance of inher (her father's father) with PKU. Jessica is married to a man nam has two phenotypically unaffected parents but he has a brothe Jessica's paternal grandmother and both maternal grandpare members mentioned, and answer the question: What is the prob have the disorder? Circle your final answer. (1.5 pts) n metabolic disorder in which affected individuals, homozygous for the recessive reakdown of excess phenylalanine. Symptoms of the disease include velopment, behavioral and social problems, poor bone strength, and neurological an equal chance of inheriting PKU. A woman named Jessica had a paternal grandfather sica is married to a man named Carl, who is phenotypically unaffected (lacks PKU). Carl red parents but he has a brother with PKU. The trait is rare so we can assume that her and both maternal grandparents were genotypically AA Draw a pedigree of these family and answer the question: What is the probability that a child produced by Jessica and Carl will PKU=aa OLA? Taa] Jessica AAAAA AAAA Aa А | AA Aok Jaa Chance AA + 1/2 chance Aa 12 chance AA + 2 chance Aa 0 ДА 5 AAQ S 1 2 Aa x Aag Ho chance Jessica and Carls offspring will have the disorder

Answer 1

rother ГАо — then aa GO AATOA Аф Г" АА mother Father brother sessica (cally Can da an. It is similar chances for mare e female ther, it iust be autosomal disorder an necessive. so.. AAS Aa . Normal aa - PKU. mal disorder and it is sessica's mother will be a because their parent both wors AA. but for fisica's father, who can be athen AA A Aa because his mother is AA s father have so. Jenice's А. Аа genotype can be As their so, Ae can s Jessica are both care children will not be PU probability of Call of bing ha)= because e otherwise patient. 7 = 2. . so. Ang geirsica to be and finally A a Z sat ng - 2. so to be affected (aa) one children probability a so, o final AA Wла Aa probability will be a 1x t =.