Homework Answers
Option (a) Tau protein, is correct answer.
Tau protein -
• In healthy brain cells, tau protein normally binds to and
stabilizes the microtubules.
• Alzheimer's disease is characterized by the presence of excess
neurofibrillary tangles and beta-amyloid deposits in neocortex,
hippocampus and amygdala.
• So, Plaques are formed by beta amyloid and neurofibrillary
tangles are formed by tau proteins.
• In Alzheimer's disease, increased activity of enzyme tau kinases
causes tau protein's misfolding and clumping, this results in
formation of neurofibrillary tangles.
• Neurofibrillary tangles composed of hyperphosphorylated tau
protein.
• Amyloid plaques are hard, insoluble accumulations of beta amyloid
proteins that clump together between the nerve cells in the brains
of Alzheimer's disease patients.
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Question 1 0.4 pts The neurofibrillary tangles seen in Alzheimer's Disease are made up of which...
1. The plaques seen in Alzheimer's Disease contain peptides that come from which protein? A. Beta...
1. The plaques seen in Alzheimer's Disease contain peptides that come from which protein? A. Beta secretase B. Tau protein C. Amyloid Precursor protein D. Huntingtin protein E. Microtubule Associated protein 2. Mutations in presinilin 1 and 2 are associated with ____________ A. Frontotemporal Dementia B. Vascular Dementia C. the familial form of Alzheimer's Disease D. Lewy Body Dementia E. the sporadic form of Alzheimer's Disease 3. What role does Apolipoprotein E (APO E) play in Alzheimer's Disease? A. It...
Question 2 0.4 pts Amyloid plaques observed in Alzheimer's disease are located and contain in the...
Question 2 0.4 pts Amyloid plaques observed in Alzheimer's disease are located and contain in the extracellular space; tau in the intracellular space; microtubule associated protein in the extracellular space; beta-amyloid in the intracellular space; beta-amyloid
24.Individuals with Alzhimer's Disease typically have which protein aggregation in the cytpolasm of affected cells? A)...
24.Individuals with Alzhimer's Disease typically have which protein aggregation in the cytpolasm of affected cells? A) beta amyloid d. beta-synuclein c. alpha-synuclein b. alpha amyloid E) tau protein
24.Individuals with Alzhimer's Disease typically have which protein aggregation in the cytpolasm of affected cells? A) beta amyloid d. beta-synuclein c. alpha-synuclein b. alpha amyloid E) tau protein
Blocking the activity of beta-secretase __ in theory be helpful in Alzheimer's Disease because would; it...
Blocking the activity of beta-secretase __ in theory be helpful in Alzheimer's Disease because would; it would reduce the amount of beta-amyloid produced would; it would result in fewer neurofibrillary tangles would not beta-secretase cuts in the middle of the peptide that would normally become beta-amyloid would not; beta-secretase is the most efficient protein involved in clearance of beta-amyloid from the brain
15. You are conducting a bioinformatics analysis on amyloid-beta protein which causes Alzheimer's disease when misfolded....
15. You are conducting a bioinformatics analysis on amyloid-beta protein which causes Alzheimer's disease when misfolded. You notice that one position in the alignment is comprised of two different amino acids across sequences. Your query sequence (the one you searched with) has a valine in this position. What is likely to be the other amino acid? (2pts) A) Glutamic acid B) Lysine C) Leucine D) Cystine E) Serine
QUESTION 1 A 75-year-old male patient diagnosed with Alzheimer's disease presents with agitation and aggressive behavior....
QUESTION 1 A 75-year-old male patient diagnosed with Alzheimer's disease presents with agitation and aggressive behavior. The PMHNP determines which of the following to be the best treatment option? O A. Immunotherapy . O B. Donepezil (Aricept) ° C. Haloperidol (Haldol) O D. Citalopram (Celexa) or Escitalopram (Lexapro) OLIESTION 2
11.Which of the following mutations would most likely to disrupt the structure of an α-helix? Cys...
11.Which of the following mutations would most likely to disrupt the structure of an α-helix? Cys to Ala Lys to Arg Glu to Gly Val to Leu 12.Which amino acid combination is the most preferred to occupy positions 1 and 4 in an α-helix? Glu and Lys Phe and Pro Lys and Arg Asp and Glu 13.If each turn in the standard alpha helix extends 5.4 A and there are 3.6 amino acid residues per turn, how many amino acids...
1 pts Question 5 Protein secondary structures consist of all of the following elements except: watson...
1 pts Question 5 Protein secondary structures consist of all of the following elements except: watson crick base pairing O alpha helix coil tum O beta sheet
D Question 44 2 pts A sufficient cause complex is made up of a necessary cause...
D Question 44 2 pts A sufficient cause complex is made up of a necessary cause and component causes. More than one component cause complex may be involved in the etiology of a disease, but the necessary cause must be in EVERY cause complex O True O False
Question 6 1 pts Inflammation in the brain is considered to be one contributing factor in...
Question 6 1 pts Inflammation in the brain is considered to be one contributing factor in the progression of Alzheimer's disease. Which of the following mediators of inflammation are activated by Abeta oligomers and plaques? Microglia O Astrocytes O Macrophages ODendrites Dendritic cells
Question 2 0.4 pts Amyloid plaques observed in Alzheimer's disease are located and contain in the extracellular space; tau in the intracellular space; microtubule associated protein in the extracellular space; beta-amyloid in the intracellular space; beta-amyloid
24.Individuals with Alzhimer's Disease typically have which protein aggregation in the cytpolasm of affected cells? A) beta amyloid d. beta-synuclein c. alpha-synuclein b. alpha amyloid E) tau protein
24.Individuals with Alzhimer's Disease typically have which protein aggregation in the cytpolasm of affected cells? A) beta amyloid d. beta-synuclein c. alpha-synuclein b. alpha amyloid E) tau protein
Blocking the activity of beta-secretase __ in theory be helpful in Alzheimer's Disease because would; it would reduce the amount of beta-amyloid produced would; it would result in fewer neurofibrillary tangles would not beta-secretase cuts in the middle of the peptide that would normally become beta-amyloid would not; beta-secretase is the most efficient protein involved in clearance of beta-amyloid from the brain
15. You are conducting a bioinformatics analysis on amyloid-beta protein which causes Alzheimer's disease when misfolded. You notice that one position in the alignment is comprised of two different amino acids across sequences. Your query sequence (the one you searched with) has a valine in this position. What is likely to be the other amino acid? (2pts) A) Glutamic acid B) Lysine C) Leucine D) Cystine E) Serine
QUESTION 1 A 75-year-old male patient diagnosed with Alzheimer's disease presents with agitation and aggressive behavior. The PMHNP determines which of the following to be the best treatment option? O A. Immunotherapy . O B. Donepezil (Aricept) ° C. Haloperidol (Haldol) O D. Citalopram (Celexa) or Escitalopram (Lexapro) OLIESTION 2
1 pts Question 5 Protein secondary structures consist of all of the following elements except: watson crick base pairing O alpha helix coil tum O beta sheet
D Question 44 2 pts A sufficient cause complex is made up of a necessary cause and component causes. More than one component cause complex may be involved in the etiology of a disease, but the necessary cause must be in EVERY cause complex O True O False
Question 6 1 pts Inflammation in the brain is considered to be one contributing factor in the progression of Alzheimer's disease. Which of the following mediators of inflammation are activated by Abeta oligomers and plaques? Microglia O Astrocytes O Macrophages ODendrites Dendritic cells
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