Alzheimer disease is caused due to protein aggregation of beta-amyloid proteins. Beta-amyloid proteins aggregate and form plaque which disrupt the normal functioning of neurons.
Alpha-synuclein plays a part in Parkinson disease.
aggregation of beta-synuclein leads to neurodegeneration.
Tau protein helps in the cytoskelton of neurons.
So correct answer is option A.
24.Individuals with Alzhimer's Disease typically have which protein aggregation in the cytpolasm of affected cells? A)...
Question 1 0.4 pts The neurofibrillary tangles seen in Alzheimer's Disease are made up of which protein? O Tau protein O Amyloid Precursor protein 0 Actin protein O Alpha Synuclein O Beta Amyloid
1. The plaques seen in Alzheimer's Disease contain peptides that come from which protein? A. Beta secretase B. Tau protein C. Amyloid Precursor protein D. Huntingtin protein E. Microtubule Associated protein 2. Mutations in presinilin 1 and 2 are associated with ____________ A. Frontotemporal Dementia B. Vascular Dementia C. the familial form of Alzheimer's Disease D. Lewy Body Dementia E. the sporadic form of Alzheimer's Disease 3. What role does Apolipoprotein E (APO E) play in Alzheimer's Disease? A. It...
Inactivation of protein P causes a disease D. The mRNA from the affected individuals in the same family had a deletion of 113 nucleotides. The comparison of the gene sequence between the affected and healthy individuals identified one nucleotide substitution. A) What could be the molecular mechanism that cause the deletion of 113 nucleotides in the mRNA? B) What can happen to the protein P as a result of this deletion? C) What can you conclude about the molecular basis...
Beta-amyloid peptides are formed when _______________ cut the ______________. A. apolipoprotein E ; presenilin protein B. alpha secretase and gamma secretase ; presenilin protein C. beta secretase and gamma secretase ; amyloid precursor protein D. alpha secretase and gamma secretase ; amyloid precursor protein
Many diseases, including Alzheimer’s disease, are associated with a.) protein aggregation b.) high ATP levels in the liver c.) buildup of uric acid d.) antibodies e.) dietary deficiencies
15. You are conducting a bioinformatics analysis on amyloid-beta protein which causes Alzheimer's disease when misfolded. You notice that one position in the alignment is comprised of two different amino acids across sequences. Your query sequence (the one you searched with) has a valine in this position. What is likely to be the other amino acid? (2pts) A) Glutamic acid B) Lysine C) Leucine D) Cystine E) Serine
5. Sickle-cell disease is an interesting genetic disease. Normal homozygous individuals (SS) have normal blood cells that are easily infected with the malarial parasite. Thus, many of these individuals become very ill from the parasite and many die. Individuals homozygous for the sickle-cell trait (ss) have red blood cells that readily collapse when deoxygenated. Although malaria cannot grow in these red blood cells, individuals often die because of the genetic defect. However, individuals with the heterozygous condition (Ss) have some...
10. Protein folding, in most cases, is complex and inhibited by aggregation. Which of the following is false regarding protein folding? A. Chaperones of the heat shock classes do not promote folding, but rather inhibit aggregation. B. Enzymes promote the formation of proper disulfide linkages by eliminating improper folding. C. All proteins require the input of energy and the assistance of chaperones for folding. D. Secondary structures usually form first in folding.
23. A protein called Ras is tethered (linked) to the plasma membranes of stem cells where it participates in signal transduction pathways that affect stem cell proliferation. Which of the following covalent modifications would be responsible for tethering (linking) the Ras to the membrane? A. Phosphorylation B. Glycosylation C. Lipid modification D. Ubiqutiylation E. Acetylation 24. What do transmembrane proteins in the peroxisome, nucleus, and mitochondria all have in common? A. They are all co-translationally inserted into the membrane B....
1.2 Mammalian (and human) red blood cells contain a large amount of hemoglobin, a protein that binds O2. Which of the following descriptions is NOT true about the protein hemoglobin? Select one: a. Different globin polypeptides are encoded by different genes.cross out b. There are two alpha-like and two beta-like polypeptides in each hemoglobin protein.cross out c. The hemoglobin protein is a homotetramer of globin polypeptides.cross out d. The functional hemoglobin protein contains four (4) globin polypeptides.cross out e. Each...