Question

QUESTION 13 Based on Figure 9-24, can you predict the position of a mutation that would produce an active protein that was not directed out of the cell for secretion? ER lumen Signal sequence Cytosol ER membrane 2015 A mutation in the NLS would cause a normally secreted protein to stay inside the cell. A mutation in the 3' UTR would produce an active but improperly secreted protein. A mutation in the ribosome would produce an active but improperly located protein. A mutation in the signal sequence could produce a protein that would not end up in the normal location.

Answer 1

Answer is: a mutatiom in the signal sequence could produce a protein taht would not end up in the normal location.

Explanation:

The signal sequence is cleaved, then polypeptide releases into the lumen of the Endoplasmic reticulum. Then this is transported to golgi body and then outside.

If the signal sequence is mutated, then protein is not released in the lumen of Endoplasmic reticulum. And it is not transported to the golgi body. Hence it remains in the cell.