drug blocks the phosphorylation of I-κB and release from NF-κB, what is the outcome for the...
drug blocks the phosphorylation of I-κB and release from NF-κB, what is the outcome for the cell?
a
Auto-phosphorylation of RTK is blocked.
b
The RAS protein is not activated.
c
The MAPK kinase cascade is blocked.
d
Transcription is not activated.
Homework Answers
The answer to the question is option d
Transcription is not activated.
The phosphorylation of I-kB inhibits the NF-kB which helps in the process of transcription.
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drug blocks the phosphorylation of I-κB and release from NF-κB,
what is the outcome for the...
Drosopholia eye development is an example of cell differentiation directed by signal binding to a receptor...
Drosopholia eye development is an example of cell differentiation directed by signal binding to a receptor tyrosine kinase (RTK). In this pathway, R7 photoreceptor development requires a receptor (SEV, sevenless), which is activated by binding to a plasma membrane bound signal (BOSS, bride-of-sevenless) displayed on the adjacent R8 cell Receptor activation leads to activation of RAS via two proteins, Drk (down- stream of receptor kinases) and Sos (son-of-sevenless). Activated RAS leads to activation of a phosphorylation cascade that activates the...
Last guy got it wrong - Thank you. 2. You discover a signal transduction pathway that...
Last guy got it wrong - Thank you.
2. You discover a signal transduction pathway that regulates actin polymerization. SigC is the ligand, which binds to and activates a receptor tyrosine kinase (RTK). Activation of the RTK leads to the activation of the Ras protein, which then activates the protein kinase PK1 that phosphorylates the RingA protein on S34. When SigC plasma membrane phosphorylated, RingA binds EXTRACELLULAR to the gene regulatory SPACE inactive Ras protein activated Ras protein protein, AP1....
2. The following is a description of a signaling pathway initiated by receptor tyrosine kinases. Ligand → RTK → Sos → Ras → Raf → MEK → ERK → Transcription factor → Cell growth A. (3pts) Which of the...
2. The following is a description of a signaling pathway initiated by receptor tyrosine kinases. Ligand → RTK → Sos → Ras → Raf → MEK → ERK → Transcription factor → Cell growth A. (3pts) Which of these steps indicates the protein is activated after a GTP exchange step? B. (3pts) Which of these proteins can be deactivated by phosphatases? C. (4pts) Describe a mutation that would cause Ras to be permanently "on"? Would this mutation lead to high...
Need help on these questions ? 1.) Steroid hormones trigger transcription of target genes by... ...
Need help on these questions ? 1.) Steroid hormones trigger transcription of target genes by... a. activating the release of Ca+2 ions that bind to and activate transcription factors. b. activating a kinase cascade that results in the activation of a transcription factor for a set of genes. c. binding directly to DNA and stimulating transcription. d. binding to nuclear receptors that act as transcription factors for specific genes. 2.) Which type of cell-surface receptor(s), when...
The cell demands to know that a stimulus to grow comes from the receptor. It does...
The cell demands to know that a stimulus to grow comes from the receptor. It does that by requiring that multiple factors or pathways are activated. Which is NOT a component of this system? A. Activation of the Ras pathway leads to apoptosis B. Activation of PI-3 kinase leads to activation of Akt (PKB) C. Activation of the Ras pathway leads to assembly of AP-1 D. Release of Nitric oxide leads to elevation of cGMP
Classes 7-8 Cytoplasmic Growth Signaling Be able to describe Ras structure and function. What kind of...
Classes 7-8 Cytoplasmic Growth Signaling Be able to describe Ras structure and function. What kind of protein is it? How is it regulated (Fig. 5.30)? How many forms of Ras do humans express? Be able to describe how Ras interacts with multiple downstream partners. What mechanisms render ras oncogenic? Also, how does Ras become oncogenic in the absence of ras mutations? Be able to describe how Ras interacts with the growth factor receptor signaling machinery. How did fly genetics help...
help with 38 I got it wrong and dont know what it is what is ras?...
help with 38 I got it wrong and dont know what it
is
what is ras? is what is missing sorry
lilleonine kinase receptors D) Nuclear receptors E) Tyrosine phosphatase receptors D 37. Which one (if any) of the following cellular events does NOT inci wing cellular events does NOT include a role for apoptosis: A) Immune function return to homeostasis following an infection B) Digit formation during development C Cellular response to irreparable DNA damage identified in G1 of...
9. Analyze the diagram below of a nuclear response for gene expression: Which of the following...
9. Analyze the diagram below of a nuclear response for gene
expression:
Which of the following is this cell using to control all of the
other events to regulate gene expression?
a. phosphate bonded to a transcription factor
b. phosphorylation cascade with multiple steps
c. specific hormone that initiates a response
d. transcription housed outside of the nucleus
10. Below is a model of a signal transduction pathway that results
in the transcribing of mRNA:
Referencing the model, what...
QUESTION 11 When a mitogen-activated signal transduction cascade is activated, what happens to (a) the phosphorylation...
QUESTION 11 When a mitogen-activated signal transduction cascade is activated, what happens to (a) the phosphorylation state of PRB and to (b) the status of PRB's E2F binding switch? (a) PRB state: phosphorylated (b) switch: ON (activated) - E2F bound CA (a) PRB state: phosphorylated B. (b) switch: OFF (inactivated) - E2F released (a) PRB state: is not phosphorylated C. (b) switch: ON (activated) - E2F bound (a) PRB state: is not phosphorylated D.(b) switch: OFF (inactivated) - E2F released
9. What happens when a trimeric G a. Ga separates from b. GB separates from the...
9. What happens when a trimeric G a. Ga separates from b. GB separates from the GaG protein is activated by the GpGy dimer dimer d. Ga, Gp, and Gy separate from each other e. The trimeric G protein localizes to the c. Gy separates from the GaGß dimer t nuceus se the folowing list to answer questions 10-13.Answers can be used more than once a. Endocytosis followed by degradation in lysosomes tqitination mediated by SOCS followed by degradation by...
Drosopholia eye development is an example of cell differentiation directed by signal binding to a receptor tyrosine kinase (RTK). In this pathway, R7 photoreceptor development requires a receptor (SEV, sevenless), which is activated by binding to a plasma membrane bound signal (BOSS, bride-of-sevenless) displayed on the adjacent R8 cell Receptor activation leads to activation of RAS via two proteins, Drk (down- stream of receptor kinases) and Sos (son-of-sevenless). Activated RAS leads to activation of a phosphorylation cascade that activates the...
Last guy got it wrong - Thank you.
2. You discover a signal transduction pathway that regulates actin polymerization. SigC is the ligand, which binds to and activates a receptor tyrosine kinase (RTK). Activation of the RTK leads to the activation of the Ras protein, which then activates the protein kinase PK1 that phosphorylates the RingA protein on S34. When SigC plasma membrane phosphorylated, RingA binds EXTRACELLULAR to the gene regulatory SPACE inactive Ras protein activated Ras protein protein, AP1....
2. The following is a description of a signaling pathway initiated by receptor tyrosine kinases. Ligand → RTK → Sos → Ras → Raf → MEK → ERK → Transcription factor → Cell growth A. (3pts) Which of these steps indicates the protein is activated after a GTP exchange step? B. (3pts) Which of these proteins can be deactivated by phosphatases? C. (4pts) Describe a mutation that would cause Ras to be permanently "on"? Would this mutation lead to high...
Classes 7-8 Cytoplasmic Growth Signaling Be able to describe Ras structure and function. What kind of protein is it? How is it regulated (Fig. 5.30)? How many forms of Ras do humans express? Be able to describe how Ras interacts with multiple downstream partners. What mechanisms render ras oncogenic? Also, how does Ras become oncogenic in the absence of ras mutations? Be able to describe how Ras interacts with the growth factor receptor signaling machinery. How did fly genetics help...
help with 38 I got it wrong and dont know what it
is
what is ras? is what is missing sorry
lilleonine kinase receptors D) Nuclear receptors E) Tyrosine phosphatase receptors D 37. Which one (if any) of the following cellular events does NOT inci wing cellular events does NOT include a role for apoptosis: A) Immune function return to homeostasis following an infection B) Digit formation during development C Cellular response to irreparable DNA damage identified in G1 of...
9. Analyze the diagram below of a nuclear response for gene
expression:
Which of the following is this cell using to control all of the
other events to regulate gene expression?
a. phosphate bonded to a transcription factor
b. phosphorylation cascade with multiple steps
c. specific hormone that initiates a response
d. transcription housed outside of the nucleus
10. Below is a model of a signal transduction pathway that results
in the transcribing of mRNA:
Referencing the model, what...
QUESTION 11 When a mitogen-activated signal transduction cascade is activated, what happens to (a) the phosphorylation state of PRB and to (b) the status of PRB's E2F binding switch? (a) PRB state: phosphorylated (b) switch: ON (activated) - E2F bound CA (a) PRB state: phosphorylated B. (b) switch: OFF (inactivated) - E2F released (a) PRB state: is not phosphorylated C. (b) switch: ON (activated) - E2F bound (a) PRB state: is not phosphorylated D.(b) switch: OFF (inactivated) - E2F released
9. What happens when a trimeric G a. Ga separates from b. GB separates from the GaG protein is activated by the GpGy dimer dimer d. Ga, Gp, and Gy separate from each other e. The trimeric G protein localizes to the c. Gy separates from the GaGß dimer t nuceus se the folowing list to answer questions 10-13.Answers can be used more than once a. Endocytosis followed by degradation in lysosomes tqitination mediated by SOCS followed by degradation by...
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