Question

Question 1: Antibiotics are effective against a population of bacteria. However, you observe a new resistance allele arises in the bacteria population. You observe the fitness of the mutant is 1% higher than the wild type and the population size (N) of the bacteria is 106. A) How long does it take for the resistance allele to reach fixation? Hint: The fixation time is defined as the time from a single copy of the resistance allele (1/N) to near fixation (1 - 1/N). (2 points) B) If the population size is 108 instead of 106, what is the fixation time? (1 point)

Answer 1

Question 1: (A). How long does it take allele to reach fixation ? for the pesistance ? Here fictness of the mutant is 1% higher than the wild type. Population size of the bactenie Nr 106 Possible copies at which a need mutant could originate is 2NE Probability of getting new mutant in Nu Total number of mutation willbefixed per generation is: 2nuxu Tuesday ... Rate at which new mutants are fixed in su So, time taken for the resistance allele to peach fixation is 1/2 cu=1) 1 unit time (B). If the population size is 108 instead of 106, What is the fiscation time? & fixation time, does not depends on population size. So, fixation time remain same.