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Why is the conversion of pyruvate to acetyl-CoA considered irreversible in animals? Why is acetyl-CoA only...

Why is the conversion of pyruvate to acetyl-CoA considered irreversible in animals? Why is acetyl-CoA only considered ketogenic and not glucogenic, even though it enters the TCA cycle to form citrate? How do plants make acetyl-CoA glucogenic?

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Acetyl co A is not glucogenic because pyruvate dehydrogenase enzyme can not make acetyp co A back into glucose thats why this process is not glucogenic and said that it is ketogenic.

Plants make acetyl co A glucogenic by the gluconeogensis concept i.e from fat and the protein they can make glucose ,firstly fatty acids,glucogenic amino acids make the acetyl co A and then pyruvate ehich is the major precursor of the glucose formation in gluconeogenesis.Lactate is also a precursor.

After the pyruvate is summed up with glycerol and amino acids to make glucose.

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