Question

________ moves Ca2+ from the ER lumen to the inter membrane space.

IP3-gated calcium channels

Voltage-dependent anion channels (VDACs)

Mitochondrial calcium uniporters (MCUs)

none of the above

Answer 1

Answer- voltage dependent anion channels (VADC's)

voltage dependent anion channels ( VADC's) moves Ca2+ from the ER leumen to the inter membrane space

Explanation-

1. Outer mitochondrial membrane has plenty of voltage dependent anion channels that plays major role in Ca2+ transport from ER leumen to intermembrane space.

2. In IP3 receptor mediated pathway mitochondrial Ca2+ transport is limited to outer mitochondrial membrane.

3. VADC forms complex with endoplasmic reticulum Ca2+ release channel IP3Rs and this complex provides highway for transport of Ca2+ from ER leumen to intermembrane space.