Question

der the following events (1 through 7, with 1 being the first and 7 being the last) as they would occur during an infection. (7 pts) TLR7 and Rig- signaling pathways are activated Virally-infected cells undergo apoptosis NK cells are stimulated to proliferate and become activated to kill Influenza virus is inhaled Type I interferons are secreted Virus enters lung epithelial cells NK cells release perforin and granzymes 8. You've just discovered a new complement effector mechanism and you want to assess the contribution of each complement pathway to this new effector mechanism. Name a single complement protein (encoded by a single gene) you could eliminate to completely knockout the Alternative Complement Pathway, while having no effect on the other two pathways. Explain the critical function of this protein in the Alternative Pathway. If there is no such single protein, answer NONE. (4 pts) b. Same question, but for the Classical Complement Pathway. Name a single complement protein you could eliminate to completely knockout the Classical Complement Pathway, while having no effect on the other two pathways. Explain the critical function of this protein in the Classical Pathway. If there is no such single protein, answer NONE. (4 pts) C. Same question, but you want to assess the contribution of the Lectin Complement Pathway alone. Name a single complement protein you could eliminate to completely knockout the Lectin Complement Pathway, while having no effect on the other two pathways. Explain the critical function of this protein in the Lectin Pathway. If there is no such single protein, answer NONE. (4 pts)

Answer 1

Part A: 7. Pathway order

1. Influenza virus is inhaled
2. Virus enters lung epithelial cell
3. TLR7 and Rig-1 signalling pathways are activated
4. Type I interferons are secreted
5. NK cells are stimulated...
6. NK cells release perforin and granzymes
7. Virally infected cells undergo apoptosis