Question

Regulation a) Please list two types of reversible covalent modification of proteins used for regulation b) How is chymotrypsin activated in the digestive system? c) Why is phosphorylation an effective means of regulating protein activity? d) What is the cascade for zymogen activation in the digestive system? e) What posttranslational modification does prothrombin undergo before it is converted to thrombin 1) What is the function of vitamin K?

Answer 1

Hello,

a)Covalent modifications are used mainly to alter the activity of a protein.The two most common types of reversible covalent modification of proteins used for regulation are acetylation and phosphorylation.For example acetylation oh histone(Proteins used for packaging of DNA).

b)Active form of chymotrysin is formed when disulfide bond between arginie-15 and isoleucine-16 present in chymotrypsinogen is cleaved by the enzyme trypsin.

Hope this helps.