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Can unprocessed antigen also make its way to lymph node B cells?

Can unprocessed antigen also make its way to lymph node B cells?

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No, unprocessed antigen usually doesn't reach to lymph nodes. Lymph nodes are the lymphoid organ where Immune response takes place. Lymph nodes consists of lymphocytes like B-lymphocytes and T-lymphocytes. When an Ag enters in the human body it will either enter into bloodstream or in tissues. Here, the Ag is unprocessed. Only Naive B cells can recognise the unprocessed Ag. Naive B cells after encountering with the Ag will become activated B cells and the processing of Ag take s place. Processing of Ag means preparing the Ag for presenting to the specific cells of Immune system i.e. T-lymphocytes (breaking into small peptide by EL complex or proteosomal mediated). So, only processed Ag makes its way to lymph nodes.

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