Methylation on DNA is majorly used for three purpose-
1)- To control the gene expression- methylation is an epigenetic modification of DNA. Methylated DNA is generally transcriptionally inactive. Methylated regions on DNA are condensed and packed tightly to give rise heterochromatin, transcriptionally inactive region of DNA. Methylation is also used in X-chromosome inactivation.
2)- To distingeus between self and non-self DNA- Bacterial endonuclease differentiate between self and viral DNA and cleave selectively viral DNA because viral DNA is unmethylated while bacterial DNA is methylated.
3)- In repair- methylation help the repair machinery to distinguish between old/template DNA and newly replicated DNA.
So option 1 and 3 is correct
Methylation • Add-CH3 groups to a few bases on DNA Why? 1. Control gene expression 2....
17-11. Methylation of eukaryotic DNA controls gene expression. a) Describe in words the control of methylation of DNA in eukaryotes. b) Describe in words how silencing starts with methylation.
Part 1. Eukaryotes use at least two distinct mechanisms to control gene expression by altering the structure of chromatin around a particular gene. One of these mechanisms is the covalent modification of histones to switch DNA between an open and closed confirmation. A second mechanism is the covalent modification of DNA (typically on cytosines) by methylation. A. Describe a type of histone modification and explain what effect is has on chromatin, and how that effect is achieved. a. One type...
Trivia Questions 1. This level of control in gene expression prevents a gene from being transcribed when it is not needed. 2. These genes produce proteins that govern the activity of structural genes. 3. These intervening sequences are cut out of an mRNA transcript before it can leave the nucleus. 4. A chromosome is made up of these two molecules. 5. This term refers to DNA that is composed of at least two species. 6. These two vectors are used...
Match the term with the process it is involved in. 1. Chromatin remodeling 2. Prokaryotic gene expression Polycistronic mRNA > 3. Promotion of expression of gene Histone de-acetylase 4. DNA binding proteins 5. DNA methylation 6. Semi-conservative replication
What control elements regulate expression of the mPGES-1 gene? The promoter of a gene includes the DNA immediately upstream of the transcription start site, but expression of the gene can also be affected by control elements. These can be thousands of base pairs upstream of the promoter, grouped in an enhancer. Because the distance and spacing of these control elements make them difficult to identify, scientists begin by deleting sections of DNA that contain possible control elements and measuring the...
Question 1 Which of the following statements is true? Promoter bashing can lead to increased DNA methylation. Methyl groups are removed from the DNA by DNA methyltransferase. ODNA methylation is directly passed on during meisos to all daughter cells. Monoallelic gene expression occurs when a mutation results in dominant gene expression. Patterns of DNA methylation are preserved in somatic cells following mitosis.
1. Write out the full name for DNA. 2. Why is the nucleus called the "control center" of the cell? 3. Where in the cell are the chromosomes located? 4. What is a gene? 5. What do proteins do for your body? 6. What holds the sides of the DNA ladder together? 7. What are the sides of the DNA ladder made of? 8. What three parts make up a single nucleotide? 9. What are the 4 bases that make...
Understanding control of gene expression by chromatin regulation We discussed how maternal grooming behavior regulates anxiety and stress response in rats. Rats raised by low-care mothers grow up to be more anxious and guarded adults. Rats raised by high-care mothers on the other hand become more relaxed adults. Below are two key results from the study that discovered this phenomenon. Scientists looked at DNA methylation in the promoter of a gene called glucocorticoid receptor which is expressed in the hippocampus...
Understanding control of gene expression by chromatin regulation We discussed how maternal grooming behavior regulates anxiety and stress response in rats. Rats raised by low-care mothers grow up to be more anxious and guarded adults. Rats raised by high-care mothers on the other hand become more relaxed adults. Below are two key results from the study that discovered this phenomenon. Scientists looked at DNA methylation in the promoter of a gene called glucocorticoid receptor which is expressed in the hippocampus...
What role does control of gene expression play in the diversity of individuals of the same species within a population, and how does this individual diversity contribute to natural selection? Point mutations within the DNA are often considered neutral, in that they have no discernable effect on the phenotype of the affected individual. Why is this the case? What properties of the genetic code contribute to the neutrality of point mutations? Why are mutations that add or subtract nucleotides within...