Question

Which of the following classes of antimicrobial drugs inhibit nucleic acid synthesis? Select ALL correct answers...

Which of the following classes of antimicrobial drugs inhibit nucleic acid synthesis?

Select ALL correct answers -- there is more than one!

Rifamycins
Pyrazinamides
Oxazolidinones
Fluoroquinolones
Nitroimidazoles
Sulfonamides
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Answer #1

Antibiotics that inhibit nucleic acid synthesis: rifamycins and quinolones.

Rifamycins

The rifamycins are a family of antibiotics that inhibit bacterial RNA polymerase. Rifamycins work by binding to the bacterial DNA-dependent RNA polymerase, the enzyme that is responsible for transcription of DNA into RNA.

The best-known and most effective member of the rifamycin family is rifampin, which is also known as rifampicin. A major use of rifampin is in the treatment of mycobacterial diseases, such as tuberculosis and leprosy.

Quinolones and Fluoroquinolones

The second major class of antibiotics that inhibit nucleic acid synthesis is the quinolones and their derivatives, the fluoroquinolones. These are synthetic antibiotics that were first developed in the 1960s. Drugs in this family, such as nalidixic acid, ciprofloxacin, and norfloxacin, work by inhibiting enzymes that are required for bacterial DNA synthesis

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