Which of the following classes of antimicrobial drugs inhibit nucleic acid synthesis?
Select ALL correct answers -- there is more than one!
Rifamycins |
Pyrazinamides |
Oxazolidinones |
Fluoroquinolones |
Nitroimidazoles |
Sulfonamides |
Antibiotics that inhibit nucleic acid synthesis: rifamycins and quinolones.
Rifamycins
The rifamycins are a family of antibiotics that inhibit bacterial RNA polymerase. Rifamycins work by binding to the bacterial DNA-dependent RNA polymerase, the enzyme that is responsible for transcription of DNA into RNA.
The best-known and most effective member of the rifamycin family is rifampin, which is also known as rifampicin. A major use of rifampin is in the treatment of mycobacterial diseases, such as tuberculosis and leprosy.
Quinolones and Fluoroquinolones
The second major class of antibiotics that inhibit nucleic acid synthesis is the quinolones and their derivatives, the fluoroquinolones. These are synthetic antibiotics that were first developed in the 1960s. Drugs in this family, such as nalidixic acid, ciprofloxacin, and norfloxacin, work by inhibiting enzymes that are required for bacterial DNA synthesis
Which of the following classes of antimicrobial drugs inhibit nucleic acid synthesis? Select ALL correct answers...
Which of the following classes of antimicrobial drugs inhibits protein synthesis? Select ALL correct answers -- there is more than one! Aminoglycosides Oxazolidinones Nitroimidazoles Chloramphenicol Pyrazinamides Fluoroquinolones
Which of the following are primary mechanisms through which microorganisms evade antimicrobial drugs? To be marked correct, you'll need to select all applicable statements, as there may be more than one correct answer. Drug target alterations Reducing drug concentration inside of the cell Drug inactivation Decreasing intracellular drug solubility
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Use the following to answer the questions below: For each of the nucleic acid situations, select the process with which it is associated using the response list. Responses may be used more than once or need not be used at all. a) translation phase of protein synthesis b) transcription phase of protein synthesis c) replication of DNA d) post-transcription phase of protein synthesis Okazaki fragments are formed.
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Select all correct options in the list below about concrete and abstract classes Select one or more: a. Concrete classes can be instantiated b. Abstract classes must contain at least one abstract method c. Only concrete classes can be super classes d. Abstract classes (using the "abc" library) can be instantiated e. Concrete classes often contain abstract methods f. Both concrete and abstract classes can be super classes that other classes inherit from g. Only abstract classes can be super...
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