Question

1. What are the genotypic frequencies of +/+, +/-and-/-in your class population? Fill in the table below with your class data. Table 1: Observed Genotypic Frequencies for the Class Category Number Homozygous 0/4 4 Heterozygous (1) 12 Homozygous (-/-) 41 Totals Frequency (# of genotypes/total) 10.07 10.21 0.72 1 = 1.0 2. What is the frequency of each allele in your class sample? Fill in the table below with your class data: Frequency Table 2: Calculated Allelic Frequencies for the Class Category Number alleles alleles

Answer 1

According to Hardy-Weinberg Equilibrium:

p+2pq+q*= 1

p2  = frequency of homozygous dominant genotype i.e. of +/+ in our case

2pq = frequency of heterozygous genotype i.e. of +/- in our case

q2 = frequency of homozygous recessive genotype i.e. of -/- in our case

According to the question;

CATEGORY	NUMBER	GENOTYPE FREQUENCY
+/+	4	4/57 = p2 = 0.07
+/-	12	12/57 = 2pq =0.21
-/-	41	41/57 = q2 = 0.72
	4+12+41 = 57	0.07+ 0.21 + 0.72 = 1.0

To calculate allele frequency,

CATEGORY	NUMBER	ALLELE FREQUENCY
+ alleles	20(because 4*2 +12)	20/114 = 0.17
- alleles	94(because 41*2 + 12)	94/114 = 0.82
	Total alleles = 114