If a patient receives a bone marrow transplant from a donor that only matches one of...
If a patient receives a bone marrow transplant from a donor that only matches one of her two MHC haplotypes, will the patient's T cells be restricted to her original haplotypes, or to those of the donor? why?
Homework Answers
Yes, sometimes the patients T cells will be restricted to her original haplotypes or to those of donor.
Reason
During transplantation, haplotype has been cross -matched. The immunodeficiency has been effectively reconstituted with haplotype-mismatched.
And also T cells function properly when it leaves the thymus because it allows T cell receptors to bind to MHC and detect cells that are infected.
T cells will not be able to recognize antigenic peptides in association with MHC class II determinants
Add Answer to:
If a patient receives a bone marrow transplant from a
donor that only matches one of...
If an individual gets an organ transplant from a genetically dissimilar donor what will happen to...
If an individual gets an organ transplant from a genetically dissimilar donor what will happen to the transplanted tissue and why? (3 pts) b. If prior to the organ transplant the recipient’s hematopoietic system is replaced by irradiation and a bone marrow transplant from the same individual who is donating the organ, what will happen to the transplanted organ and why? [assume that the bone marrow transplant is successful and there is no Graft vs. host disease].
just question #2 Lymphocyte Development 1. B cell development in the bone marrow shares may features...
just question #2
Lymphocyte Development 1. B cell development in the bone marrow shares may features with T cell development in the thymus. A) Discuss what you consider to be the two major goals of lymphocyte development (i.e. what is the purpose of the Bone marrow and Thymus environments). B) Describe what occurs during the Precursor B cell stage and identify/describe the analogous stage in T cells. 2. With regards to what we've discussed regarding T cell development and alloreactivity,...
Fifty patients with leukemia received a bone marrow transplant with marrow from a sibling. Some o...
Fifty patients with leukemia received a bone marrow transplant with marrow from a sibling. Some of these patients died or relapsed and some were alive without relapse at the end of the study Interest is in the probabilty of being alive without relapse after a year. In particular, interest is in whether there is significant evidence that this probability is less than the corresponding probability for individuals who had their own bone marrow reinfused. Past data indicates that the latter...
2. Fifty patients with leukemia received a bone marrow transplant with marrow from a sibling. Som...
please do a) b) and c)
2. Fifty patients with leukemia received a bone marrow transplant with marrow from a sibling. Some of these patients died or relapsed and some were alive without relapse at the end of the study Interest is in the probabilty of being alive wit hout relapse after a year. In particul ar, interest is in whether there is significant evidence that this probability is less than the corresponding probability for individuals who had their own...
Practice Questions 61 15. A patient had a bone marrow transplant and numerous blood transfusions during...
Practice Questions 61 15. A patient had a bone marrow transplant and numerous blood transfusions during the course of treatment for cancer. A bone marrow biopsy performed to monitor for recurrence a few weeks after treatment ended, showed abundant hemo siderin within macrophages. In this case, hemo- siderin accumulation is not likely due to A. deposition of immunoglobulin light chains produced by the patient's cancer. B. brown atrophy. C. excess dietary lipid. D. iron overload from blood transfusions. 16. Which...
ANSWER ALL THE QUESTIONS FULLY AND CORRECTLY!!! 1) A patient has inherited two defective genes for...
ANSWER ALL THE QUESTIONS FULLY AND CORRECTLY!!!
1) A patient has inherited two defective genes for TAP2 (remember the case study from before) Which of the following are true? (circle all that apply): - The patient will have a scarcity of CD4+ T helper cells -MHC class I molecules will not be expressed to any extent on the patient's cells -MHC class II molecules will be reduced in expression - The patient will have an impaired ability to fight viral...
1. Cyclosporin A and rapamycin are each used as T cell immunosuppressants. They share the property...
1. Cyclosporin A and rapamycin are each used as T cell immunosuppressants. They share the property of binding to immunophilin molecules in T cells as the initial step in their mechanisms of action. However, in the case of cyclosporin A, the drug:immunophilin complex binds to and inhibits the protein phosphatase calcineurin, whereas the rapamycin:immunophilin complex binds to and inhibitors mTOR. As a consequence a. Cyclosporin A, but not rapamycin, blocks cytokine production by T cells. b. Both cyclosporin A and...
Could you help with any of these ? and provide an explanation so I'll understand? thank...
Could you help with any of these ? and provide an explanation
so I'll understand? thank you so much
Circle all that apply 1) A patient has inherited two defective genes for TAP2 (remember the case study from before) Which of the following are true? (circle all that apply): - The patient will have a scarcity of CD4+ T helper cells -MHC class I molecules will not be expressed to any extent on the patient's cells -MHC class II molecules...
2. What is the only location from which one can isolate ESC? 3. In what year did the first succes...
2. What is the only location from which one can isolate ESC? 3. In what year did the first successful bone marrow transplant occur? 4. What is meant by the terms: totipotent, pluripotent, and multipotent. Give a cell example for each. 5. Describe an alternative method, using stem cell technology, to study diseased tissue. 6. Propose a mechanism of using stem cells to treat reproductive disorders. 7. (a) According to the authors, why is stem cell research controversial in America?...
please answer!!? Q6. 16pt Relationship between heart and ventilation rates. Relationship between heart and ventilation rates...
please answer!!?
Q6. 16pt Relationship between heart and ventilation rates. Relationship between heart and ventilation rates Q6.1 (3pt] Calculate the heart rate (in beats per minute) from the simplified ECG in the graph above. Is the rhythm regular or irregular? (Show your work) - Heart rate (ECG) Ventilation rate dal volume) 6 Time (seconds) 06.2 (3pt) Calculate the ventilation rate (in breaths per minute) from the simplified tidal volumes in the graph above (Show your work) Q7. 16pt] Paul has...
just question #2
Lymphocyte Development 1. B cell development in the bone marrow shares may features with T cell development in the thymus. A) Discuss what you consider to be the two major goals of lymphocyte development (i.e. what is the purpose of the Bone marrow and Thymus environments). B) Describe what occurs during the Precursor B cell stage and identify/describe the analogous stage in T cells. 2. With regards to what we've discussed regarding T cell development and alloreactivity,...
Fifty patients with leukemia received a bone marrow transplant with marrow from a sibling. Some of these patients died or relapsed and some were alive without relapse at the end of the study Interest is in the probabilty of being alive without relapse after a year. In particular, interest is in whether there is significant evidence that this probability is less than the corresponding probability for individuals who had their own bone marrow reinfused. Past data indicates that the latter...
please do a) b) and c)
2. Fifty patients with leukemia received a bone marrow transplant with marrow from a sibling. Some of these patients died or relapsed and some were alive without relapse at the end of the study Interest is in the probabilty of being alive wit hout relapse after a year. In particul ar, interest is in whether there is significant evidence that this probability is less than the corresponding probability for individuals who had their own...
Practice Questions 61 15. A patient had a bone marrow transplant and numerous blood transfusions during the course of treatment for cancer. A bone marrow biopsy performed to monitor for recurrence a few weeks after treatment ended, showed abundant hemo siderin within macrophages. In this case, hemo- siderin accumulation is not likely due to A. deposition of immunoglobulin light chains produced by the patient's cancer. B. brown atrophy. C. excess dietary lipid. D. iron overload from blood transfusions. 16. Which...
ANSWER ALL THE QUESTIONS FULLY AND CORRECTLY!!!
1) A patient has inherited two defective genes for TAP2 (remember the case study from before) Which of the following are true? (circle all that apply): - The patient will have a scarcity of CD4+ T helper cells -MHC class I molecules will not be expressed to any extent on the patient's cells -MHC class II molecules will be reduced in expression - The patient will have an impaired ability to fight viral...
Could you help with any of these ? and provide an explanation
so I'll understand? thank you so much
Circle all that apply 1) A patient has inherited two defective genes for TAP2 (remember the case study from before) Which of the following are true? (circle all that apply): - The patient will have a scarcity of CD4+ T helper cells -MHC class I molecules will not be expressed to any extent on the patient's cells -MHC class II molecules...
2. What is the only location from which one can isolate ESC? 3. In what year did the first successful bone marrow transplant occur? 4. What is meant by the terms: totipotent, pluripotent, and multipotent. Give a cell example for each. 5. Describe an alternative method, using stem cell technology, to study diseased tissue. 6. Propose a mechanism of using stem cells to treat reproductive disorders. 7. (a) According to the authors, why is stem cell research controversial in America?...
please answer!!?
Q6. 16pt Relationship between heart and ventilation rates. Relationship between heart and ventilation rates Q6.1 (3pt] Calculate the heart rate (in beats per minute) from the simplified ECG in the graph above. Is the rhythm regular or irregular? (Show your work) - Heart rate (ECG) Ventilation rate dal volume) 6 Time (seconds) 06.2 (3pt) Calculate the ventilation rate (in breaths per minute) from the simplified tidal volumes in the graph above (Show your work) Q7. 16pt] Paul has...
Most questions answered within 3 hours.
-
Using the sample PV system below, calculate the wire sizes
needed for various portions of the...
asked 8 minutes ago -
Compare and contrast the atrioventricular with the semilunar
valves.
Explain what a blood pressure of 120/80...
asked 5 minutes ago -
The depth of an exoplanet "transit" light curve is most directly
related to: Group of answer...
asked 8 minutes ago -
the
force between two 2.11 x 10^-4 C charges that are 2.11 meters apart
is ______N?
asked 6 minutes ago -
Write a Java program to prompt for inputting an integer N, then
enter N integers (a...
asked 11 minutes ago -
You see a game at a local fair. You have to throw a dart at a...
asked 34 minutes ago -
AVX Home Entertainment, Inc., recently began a “no-hassles”
return policy. A sample of 505 customers who...
asked 27 minutes ago -
Which of the following would be considered criminal fraud?
[select all that apply]
trademark counterfeiting
issuing...
asked 27 minutes ago -
What is involved in collecting requirements for a
project? Why is it often difficult to do?...
asked 21 minutes ago -
9. Go to the CDC website. What is a current outbreak in the US
(something other...
asked 27 minutes ago -
in
a certain experiment 5.280 g of hydrochloric acid (HCl) reacts with
excess calcium carbonate (CaCO3)....
asked 36 minutes ago -
Cadmium is a metal that is soft and bluish-white in color.
Cadmium was used for a...
asked 36 minutes ago