Question

Lymphocyte Development 1. B cell development in the bone marrow shares may features with T cell development in the thymus. A) Discuss what you consider to be the two major goals of lymphocyte development (i.e. what is the purpose of the Bone marrow and Thymus environments). B) Describe what occurs during the Precursor B cell stage and identify/describe the analogous stage in T cells. 2. With regards to what we've discussed regarding T cell development and alloreactivity, explain how negative selection plays a role, as depicted below. Include in your explanation the MHC genotypes of the cells involved in the negative selection process. Donor H-2 Bone Marrow Donor Irradiated H-2 Bone Marrow Destroyed H-2db reconstituted H-2 Chimera Mickey H-2 H-2 reconstituted H-2 Skin Recipient Graph Accepted Skin Donor H-2 Skin Recipient Graph Rejected

just question #2

Answer 1

ANSWER:-

Irradiation of bone marrow will lead to destroy of bones marrow. after irradiation the irradiated mouse will easily accept the different graft

(H-2 b/d.). Thus after graft, this mouse will be chimeric for both of the MHC geno type.

Now if this chimeric mice will transplanted with H-2d donor now this chimeric mice will easily accept the graft .

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