What is meant by the terms "positive sense" and negative sense" when referring to a viral...

Question

Question

What is meant by the terms "positive sense" and negative sense" when referring to a viral genome?

Answer 1

Answer #1

Positive sense virus

virus with single stranded RNA
ssRNA genomes present
uses ssRNA as genetic material
ssRNA can act as messenger RNA and can cause translation of proteins in the host
Eg: picornavirus, flavi virus

Negative sense virus

ssRNA can't be used as messenger RNA
single stranded RNA virus
ssRNA used as genetic material
It is complementary to mRNA and can be converted to positive sense by RNA polymerase before translation.
highly complex
it can suppress innate immunity of cells of host
eg: boronavirus, filivirus

Answer 2

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