What kind of mutation does the Glu to Val mutation represent? Explain your answer for each....

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What kind of mutation does the Glu to Val mutation represent? Explain your answer for each....

What kind of mutation does the Glu to Val mutation represent? Explain your answer for each.

Silent vs. Missense vs. Nonsense

Gain of function vs. Loss of function

Transversion vs. transition

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Answer 1

Answer #1

Codons for glu - GAA, GAG

Codons for val - GUU, GUA, GUG, GUC

This is a missense mutation because one amino acid is changed to another amino acid. (In silent mutation, amino acid is not changed and in nonsense mutation, stop codon is formed).

We cannot see if it is a gain of function mutation or loss of function mutation because it will depend upon the functioning of abnormal protein formed after this mutation.

This mutation will occur when A will change to U. A is purine and U is pyrimidine. So, this is transversion. (In transition, purine changes to purine and pyrimidine changes to pyrimidine).

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Answer 2

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