Question

Question 5 3 pts The drug chloroquine has been widely used to treat the human parasite malaria. Mutations in the malaria gene pfcrt confer resistance to chloroquine. In some countries, more than 90% of malaria parasites had the pfcrt resistance alleles. When these countries stopped using chloroquine, the frequency of the pfcrt resistance alleles rapidly declined to less than 5% of alleles. Provide an evolutionary explanation for why the drug-resistant version of the pfcrt allele would decline so quickly. HTML Editores BIVA -A - IX E 23 3 x x : E BELI ? NV • o 12pt - Paragraph - O words

Answer 1

Ans : This study addressess the evolutionary dynamics of antimalarial drug resistance after changes in drug use.

This reversion was caused by the acquisition of a single additional C350R substitution in Pfcrt. This is done by Genome editing. In Genome editing, the adaptive changes at other amino acid positions or loci in the genome helps in the Pfcrt fixation and can lose their utility by mutation process.That is why pfcrt allele declined quickly.