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In the case of a helper cell, it can differentiate into T cells which will activate cells T helper 1 T-cell activation begins
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In the case of CD4 cell, it can differentiate into T - helper 1 cells which will activate phagocytic cells.

Activation of T-cells begins when an APC delivers antigen to a CD4 and CD8 cells.

In contrast, CD8 T cell activation requires the action of T helper 1 cells in order to differentiate into memory CD8 cells and Activated CD8 cells.

Activated CD8 cells will mount a direct attack cells through the action of perforins , which punch holes in the membranes , and Granzymes can passthrough .

It may also differentiate into a T helper 2 for B cell activation or T helper 17 cell or T-regulatory for modulation of the inflammatory response.

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