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3. The major pathways we have discussed in this section of the course focus on glycolysis, gluconeogenesis, glycogen synthesi

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Energy charge is calculated from concentrations of adenine nucleotides ([ATP + 1/2ADP]/[ATP + ADP + AMP]), and is a reflection of metabolic potential available to an organism.

Net energy charge varies between 0.7 to 0.95 and when energy charge increase from 0.6 to 1.0 anabolic pathway that uses ATP is activated and when it is low the AMP can be converted to hypoxanthine and ribose-5P, followed by oxidation of hypoxanthine to uric acid. This helps to maintain energy charge by decreasing the total ATP+ADP+AMP concentration.

Physiological process

0.8

0.97

Glycolysis

High

Low

Gluconeogenesis

Low

HIgh

Glycogen synthesis

Low

High

Glycogenolysis

High

Low

TCA cycle

High

Low

ETC

High

Low

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