Question

What approach will you use to develop a vaccine against cornavirus and why?

Conventional Vs. Evolving Vaccinology Typical features of pathogen Vaccine approach Low antigenic variability Polio Antibody-mediated immunity dominant MMR Tetanus Influenza Diphtheria MenB Licensed vaccines Conventional vaccinology Whole cell vaccines (killed or live attenuated) Subunit Recombinant Conjugate (b) High antigenic variability and/or T-cell-dependent immunity more significant Evolving vaccinology Reverse vaccinology Reverse engineering/ structural vaccinology -omics" GBS Staphylococcus Pneumococcus Chlamydia Gonorrhea Malaria Parasite diseases TB HIV No vaccine available

Answer 1

Will use the Conventional vaccinology approach. Beacuse of the high antigenic variability of the corona virus. Antigenic variability enables the pathogen to avoid the immune responses in the host. Also allows re-infection of previously infected host. Antigenic variation can also result in gene conversion,DNA inversion and hyper mutation.

So in conventional vaccinology approach the whole cell get vaccine with attenuated (Attenuated is a vaccine created by reducing the virulence of a pathogen but still keeping it viable. Attenuation takes an infectious agent and alter it so that it becomes harmless or less virulent). Or by the subunit. Subunits or protein subunits contain fragment of the microorganism that can make a immune response against the pathogen.