Question

Match each type of antimicrobial agent with a mechanism of action that describes at least one agent within the group.

biocides

target ergosterol synthesis            nucleoside analogs            targets transpeptidases in cell wall synthesis            may denature proteins or dissolve membranes   

antifungal agents

target ergosterol synthesis            nucleoside analogs            targets transpeptidases in cell wall synthesis            may denature proteins or dissolve membranes      

antiviral agents

target ergosterol synthesis            nucleoside analogs            targets transpeptidases in cell wall synthesis            may denature proteins or dissolve membranes      

antibacterial agent

Same options as above

Answer 1

Ans -

biocides - May denature proteins or dissolve membranes.

Anti fungals - Target ergosterol synthesis .

Antifungal drugs inhibit enzymes such as 14 alpha demethylase which catalyses demethylation in the pathway of synthesis of ergosterol and acculates other toxic sterols while some antifungal drugs bind to ergosterol molecules physically and form polar membrane pores . Theses pores increase permeability to proteins and cations damaging cell.

Antivirals - Nucleoside analogs .

Antiviral drugs are nucleoside analogs have a similar structure to nucleoside and so competes with nucleoside to bind to the active site of polymerase enzyme terminating the chain .

Antibacterial - Targets transpeptidases in cell wall synthesis .

For eg in beta lactam antibiotics such as penicillin attaches to PBp or penicillin binding proteins ( sub mbers of the group transpeptidases) in the cell wall of bacteria , pbp's are enzymes which cross link the peptidoglycans in biosynthesis of cell wall and inhibit cell wall synthesis .

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