Would protonation of key residues of hemoglobin after a decrease in blood pH favor formation of...
Homework Answers
The protonation states of the histidine residues key to the function of deoxy (T-state) human hemoglobin after a decrease in blood pH favor formatio of T state.
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Would protonation of key residues of hemoglobin after a decrease in
blood pH favor formation of...
Respiratory alkalosis leads to a shift of hemoglobin to the active R state. At first, it...
Respiratory alkalosis leads to a shift of hemoglobin to the active R state. At first, it may be unclear why shifting to the R state is a bad thing, but the reason should be clear shortly. First, let us examine how CO, also affects hemoglobin directly. CO2 has a direct effect on hemoglobin In addition to its indirect effect on hemoglobin structure through its effect on pH, CO, also directly affects hemoglobin by reacting with the amino-terminal residue of each...
Question 4 (1 point) In which of following people will the hemoglobin in their blood stream...
Question 4 (1 point) In which of following people will the hemoglobin in their blood stream have the highest affinity for Oz? O A person resting on the beach A person running on the beach A person skiing vigorously at high altitude A person resting at high altitude Question 5 (1 point) Which of the following interactions causes a change from the R state (oxy form) to the T state (deoxy form) of hemoglobin? interactions between heme groups protonation of...
Which of the following statement(s) is/are TRUE regarding the binding of oxygen to hemoglobin? A. The pH difference bet...
Which of the following statement(s) is/are TRUE regarding the binding of oxygen to hemoglobin? A. The pH difference between the lungs and the surrounding tissues that decreases efficiency in oxygen transport is known as the Bohr effect. B. 100% of CO2 is transported by formation of a carbamate bond with the amino terminal residues in the hemoglobin chains. C. 2,3-Bisphosphoglycerate stabilizes the T state. D. All of the statements are true.
In the Bohr effect, protonation of the imidazolium rings of the C-terminal rings of the C-terminal...
In the Bohr effect, protonation of the imidazolium rings of the C-terminal rings of the C-terminal residues (His 126B) of the hemoglobin's two B chains is responsible for around 40% of the .60 mole of H+ that combine with Hb on the release of 1.00 mole of O2 at pH 7.40. Assuming that this imidazolium group has pKa = 7.10 in R-state oxyHb, what is its pKa value in T-state deoxyHb? (Hint: the pH of the blood - because it's...
In the Bohr effect, the protonation of the N-terminal amino groups in the alpha chains of...
In the Bohr effect, the protonation of the N-terminal amino groups in the alpha chains of hemoglobin is responsible for 30% of the 0.6moles of H+ that combine with hemoglobin when 1 mole of O2 is released at pH 7.4. Assuming that the N-terminial amino groups have a pKeq of 7.0 in the R state, what is the pKeq in the T state?
For the video response portion of this assignment, your job will be to state what would happen to the oxygen bond to Hem...
For the video response portion of this assignment, your job will be to state what would happen to the oxygen bond to Hemoglobin if the pH of the tissue was the same as that of the lungs using the logic of the person’s presentation you watched. Discuss whether or not you agree with this. The video said this: Oxygen must be transported in the blood from the lungs, because the partial pressure of oxygen (pO2) is relatively high (approximately 100...
8. Enzymes often exhibit pH-dependent activity due to protonation/deprotonation of key amino acids. A general schematic...
8. Enzymes often exhibit pH-dependent activity due to protonation/deprotonation of key amino acids. A general schematic is shown in i) for a pH-dependent enzyme, in which the "active" pathway requires EH and ESH. The constants ka, kz, kcat are the usual rate constants for the Michaelis-Menten reaction scheme, and the dissociation constants KEI, KESI, KE2, Kesz are defined as shown in ii). a. Derive a M-M rate equation for the pH-dependent scheme, below. To do so: 1) express total enzyme...
1. If you were to run a SP-sepharose column equilibrated with a buffer at pH 7,...
1. If you were to run a SP-sepharose column equilibrated with a buffer at pH 7, what would be the range of pIs of the proteins that you expect to bind to the column fully? 2. In hemoglobin Rainer, Tyr 145 in the β subunit is replaced by Cys, which forms a disulfide bond with another Cys residues in the same subunit. This prevents the format of ion pairs that normally stabilize the T state. How does hemoglobin Rainer differ...
A. . Hyperpnea would result in ___________________________ within the blood. an increase in both Pressure (oxygen)...
A. . Hyperpnea would result in ___________________________ within the blood. an increase in both Pressure (oxygen) and Pressure (carbon dioxide) 2. Decreased Pressure (carbon dioxide) results in an increase in blood pH levels. Both of these conditions result in a shift of the oxygen-hemoglobin dissociation curve to the ______________________. This shift _______________ hemoglobin’s affinity for oxygen. select 3. Increased levels of 2,3 BPG occur in response to decreased blood pH levels. With all other variables unchanged, an increased concentration of...
11. Which would increase the pH of blood? A. an increase in CO2 in the blood...
11. Which would increase the pH of blood? A. an increase in CO2 in the blood B. a decrease in CO2 in the blood Which is TRUE about plasma? Check all that apply. A. it contains proteins including fibrin and collagen B. it is mostly water C. it transports nutrients, ions, hormones and gases D. it makes up about 45% of the volume of blood Which is NOT true about white blood cells? Check all that apply. A. they are...
Respiratory alkalosis leads to a shift of hemoglobin to the active R state. At first, it may be unclear why shifting to the R state is a bad thing, but the reason should be clear shortly. First, let us examine how CO, also affects hemoglobin directly. CO2 has a direct effect on hemoglobin In addition to its indirect effect on hemoglobin structure through its effect on pH, CO, also directly affects hemoglobin by reacting with the amino-terminal residue of each...
Question 4 (1 point) In which of following people will the hemoglobin in their blood stream have the highest affinity for Oz? O A person resting on the beach A person running on the beach A person skiing vigorously at high altitude A person resting at high altitude Question 5 (1 point) Which of the following interactions causes a change from the R state (oxy form) to the T state (deoxy form) of hemoglobin? interactions between heme groups protonation of...
8. Enzymes often exhibit pH-dependent activity due to protonation/deprotonation of key amino acids. A general schematic is shown in i) for a pH-dependent enzyme, in which the "active" pathway requires EH and ESH. The constants ka, kz, kcat are the usual rate constants for the Michaelis-Menten reaction scheme, and the dissociation constants KEI, KESI, KE2, Kesz are defined as shown in ii). a. Derive a M-M rate equation for the pH-dependent scheme, below. To do so: 1) express total enzyme...
11. Which would increase the pH of blood? A. an increase in CO2 in the blood B. a decrease in CO2 in the blood Which is TRUE about plasma? Check all that apply. A. it contains proteins including fibrin and collagen B. it is mostly water C. it transports nutrients, ions, hormones and gases D. it makes up about 45% of the volume of blood Which is NOT true about white blood cells? Check all that apply. A. they are...
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