Question

Please answer all of the following questions and show all work as well please.

As you already know, sickle-cell anemia is caused by an autosomal recessive trait. One of your friends is seeking some genetics advice. They (Lia and Scott) are planning on having a child and want to know what the probability is that their child will have sickle-cell disease. Lia is phenotypically normal, but we do not know anything about her family history. Scott's sister has sickle-cell disease, but both he and his parents are phenotypically normal. The frequency of the sickle-cell disease allele is approximately 15% where Lia and Scott live. The probability that their child will have sickle-cell disease is... 1 4.35% 4.25% (3) 6.53% 4 6.38%

Answer 1

Mutation acting alone -> Izcales new alleles which get naturally selected alters allele frequencies & reduces divergence . allele frequencies alter by random chance 3 resultina Bettieve en netvento - EXPTNO in over-lapstoere Date: 0 drastic coresentation of allele's

is b - f(a) = 0.15 if(A) = 1-0.15 085 f. (Aa) = 2pq , "=210-15)(0.85) CS 301255 with p(child has sickle-cell analinia = plin being a carrier) x PiScott being a carries) X Piboth contou a buling 'a' to choteld? = (0255) * (22) x (94) = 0.0425 porte -425% CamScanner