Question

Regulation of mammalian PDC: leads to decreased acetyl-CoA production in response to increased intracellular Ca2+ levels. leads to phosphorylation of the enzyme in response to increased pyruvate levels. is accomplished, in part, by competitive inhibition of E2 by pyruvate. is accomplished, in part, by NADH that activates dephosphorylation of PDC. is accomplished, in part, by pyruvate dehydrogenase phosphatase that leads to PDC activation

Answer 1

Answer-

According to the given question-

PDC- pyruvate dehydrogenase complex is a structure that are made up of 3 different enzymes namely

• E1 is called  pyruvate dehydrogenase
• E2 is called dihdrolipoyl transacetylase
• E3  is called  dihyrdolipoyl dehydrogenase

This enzyme is responsible for irreversible convertion of  Pyruvate into  acetyl-CoA which enter into citric acid cycle. The pyruvate dehydrogenase complex is regulated by feedback inhibition by cetyl-CoA. and NADH.

The Phosphorylation of pyruvate dehydrogenase complex leads to deactivation of complex while NADH and  ATP stimulate kinase activity that are responsible for deactivation of pyruvate dehydrogenase complex .

phosphatase activity is stimulated by Ca2+ that leads to Activation of pyruvate dehydrogenase complex .  

So the correct answer for the question is Regulation of mammalian pyruvate dehydrogenase complex is (E) is accomplished , in part, by pyruvate dehydrogenase phosphatase that leads to pyruvate dehydrogenase complex activation.