HMG CoA Reductase Catalyzes the first committed step in fatty acid synthesis True or false
HMG CoA Reductase Catalyzes the first committed step in fatty acid synthesis
True or false
Homework Answers
Answer is false.HMG CoA reductase is a rate limiting enzyme of mevalonate pathway lead to the formation of cholesterol.
Acetyl CoA carboxylase catalyzes the first commited step in fatty acid synthesis.The cytosolic acetyl CoA is carboxylated to malonyl CoA by this enzyme.
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HMG CoA Reductase Catalyzes the first committed step in fatty
acid synthesis
True or false
The synthesis of ____________ is the first committed step of fatty acid synthesis and the enzyme...
The synthesis of ____________ is the first committed step of fatty acid synthesis and the enzyme that catalyzes this reaction,_____________ is the major site of regulation of fatty acid synthesis.
Reaction I is the first committed step in fatty acid synthesis, and reaction II is the...
Reaction I is the first committed step in fatty acid synthesis, and reaction II is the first step in the conversion of pyruvate to glucose in gluconeogenesis. Both acetyl-CoA and pyruvate are carboxylated at the expense of ATP. What is the chemical logic behind this energy expenditure in both cases? For full marks, provide your answer with reaction schemes and electron pushing arrows.
Need help with both questions, thank you! Question 13 The committed step of fatty acid synthesis...
Need help with both questions, thank you!
Question 13 The committed step of fatty acid synthesis is catalyzed by the enzyme acetyl CoA carboxylase. Which of the following accurately describes this enzyme? None of the choices is correct. All of the choices are correct Phosphorylation of the enzyme inhibits its activity. The inhibited enzyme can be stimulated by allosteric regulation of citrate. The dephosphorylated enzyme is active. Question 14 Formation of this molecule is the committed step of fatty acid...
Statin drugs, like Mevacor (lovastatin) and Lipitor (atorvastatin), act as competitive inhibitors of HMG-CoA reductase by...
Statin drugs, like Mevacor (lovastatin) and Lipitor (atorvastatin), act as competitive inhibitors of HMG-CoA reductase by mimicking the structure of mevalonate. However, it is not this inhibition that directly lowers cholesterol levels in the blood. What enzymatic reaction does HMG CoA-reductase catalyze? What is important about this step of cholesterol synthesis? How can statins mechanistically cause a decrease in LDL cholesterol in the blood if it is not a direct effect of decreased cellular cholesterol synthesis?
HMG-CoA reductase, a critical enzyme in cholesterol synthesis is the target or statin inhibitors. You are characterizin...
HMG-CoA reductase, a critical enzyme in cholesterol synthesis is the target or statin inhibitors. You are characterizing a possible new inhibitor and want to determine its mode of binding to HMG-CoA reductase. Equilibrium dialysis measurements at 25°C, 30°C, and 37°C yielded dissociation constants (Ks) of 2.5 x 10* M, 1.5 x 10*, and 1.0 x 10* M, respectively, for the HMG- CoA reductase-inhibitor complex a. Is the binding becoming better or worse with increasing temperature? Explain. b. Using Excel or...
HMG-CoA reductase, a critical enzyme in cholesterol synthesis is the target or statin inhibitors. You are characteri...
HMG-CoA reductase, a critical enzyme in cholesterol synthesis is the target or statin inhibitors. You are characterizing a possible new inhibitor and want to determine its mode of binding to HMG-CoA reductase. Equilibrium dialysis measurements at 25 C, 30°C, and 37 C yielded dissociation constants (K.) of 2.5 x 10" М, 1.5 x 10", and 1.0 x 103 M, respectively, for the HMG-CoA reductase-inhibitor complex. a. Is the binding becoming better or worse with increasing temperature? Explain. b. Using Excel...
9. a. Describe the various ways that Acetyl-CoA Carboxylase, the first committed step of fatty acid...
9. a. Describe the various ways that Acetyl-CoA Carboxylase, the first committed step of fatty acid biosynthesis, is regulated. b. Predict whether this enzyme is likely to be active in the fed state or the fasted state, and provide a rationale for how this activation occurs given your answer to part a.
SERBP, SCAP, Insig and Sec are proteins associated with regulating the synthesis of HMG-CoA reductase and...
SERBP, SCAP, Insig and Sec are proteins associated with regulating the synthesis of HMG-CoA reductase and other enzymes of cholesterol synthesis and uptake. What compounds bind to SCAP and Insig to down-regulate HMG- CoA reductase and cholesterol synthesis? A. ammonia and urea, B. glutamate and glutamine, OC. sterols and oxysterols, OD IMP and OMP, O E. all of the above, OF none of the above, QUESTION 15 The synthesis of which of the following compounds requires the most ATP and...
1. Which of the following is true? a. The main rate-limiting step for fatty acid breakdown...
1. Which of the following is true? a. The main rate-limiting step for fatty acid breakdown is the transfer of the fatty acyl group to carnitine, with release of CoA. b. Elongase activity is an enzyme functionality of fatty acid synthase that adds 2-carbon acetyl groups to increase the length of palmitate. c. Oligomycin directly inhibits Complex I in the electron transport chain d. Squalene synthase catalyzes the rate-limiting step of fatty acid synthesis.
In the first step of fatty acid synthesis, _a___ is carboxylated. The carboxyl group is then...
In the first step of fatty acid synthesis, _a___ is carboxylated. The carboxyl group is then transferred to _b_, which becomes _C_ Oa) acetyl coA, b) biotin, c) malonyl coA a) biotin, b) acetyl coA, c) malonyl coA a) malonyl coA, b) biotin, c) acetyl coA
Need help with both questions, thank you!
Question 13 The committed step of fatty acid synthesis is catalyzed by the enzyme acetyl CoA carboxylase. Which of the following accurately describes this enzyme? None of the choices is correct. All of the choices are correct Phosphorylation of the enzyme inhibits its activity. The inhibited enzyme can be stimulated by allosteric regulation of citrate. The dephosphorylated enzyme is active. Question 14 Formation of this molecule is the committed step of fatty acid...
HMG-CoA reductase, a critical enzyme in cholesterol synthesis is the target or statin inhibitors. You are characterizing a possible new inhibitor and want to determine its mode of binding to HMG-CoA reductase. Equilibrium dialysis measurements at 25°C, 30°C, and 37°C yielded dissociation constants (Ks) of 2.5 x 10* M, 1.5 x 10*, and 1.0 x 10* M, respectively, for the HMG- CoA reductase-inhibitor complex a. Is the binding becoming better or worse with increasing temperature? Explain. b. Using Excel or...
HMG-CoA reductase, a critical enzyme in cholesterol synthesis is the target or statin inhibitors. You are characterizing a possible new inhibitor and want to determine its mode of binding to HMG-CoA reductase. Equilibrium dialysis measurements at 25 C, 30°C, and 37 C yielded dissociation constants (K.) of 2.5 x 10" М, 1.5 x 10", and 1.0 x 103 M, respectively, for the HMG-CoA reductase-inhibitor complex. a. Is the binding becoming better or worse with increasing temperature? Explain. b. Using Excel...
SERBP, SCAP, Insig and Sec are proteins associated with regulating the synthesis of HMG-CoA reductase and other enzymes of cholesterol synthesis and uptake. What compounds bind to SCAP and Insig to down-regulate HMG- CoA reductase and cholesterol synthesis? A. ammonia and urea, B. glutamate and glutamine, OC. sterols and oxysterols, OD IMP and OMP, O E. all of the above, OF none of the above, QUESTION 15 The synthesis of which of the following compounds requires the most ATP and...
In the first step of fatty acid synthesis, _a___ is carboxylated. The carboxyl group is then transferred to _b_, which becomes _C_ Oa) acetyl coA, b) biotin, c) malonyl coA a) biotin, b) acetyl coA, c) malonyl coA a) malonyl coA, b) biotin, c) acetyl coA
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