Homework Answers
Can be found in mitochondria of eukaryotic cells.
Pyrivate dehydrogenase complex is responsible for conversion of pyruvate to Acetyl CoA by reduction of NAD+ to NADH .
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QUESTION 2 The pyruvate dehydrogenase complex O a. leads to the formation of coenzyme A (COA)....
The step in metabolism that converts pyruvate to acetyl-CoA involves pyruvate dehydrogenase complex is shown. NADH...
The step in metabolism that converts pyruvate to acetyl-CoA involves pyruvate dehydrogenase complex is shown. NADH NAD Correm A CEO CH co G Pyruvate AwA What is true about this step? ATP is required but not shown The enzyme is a multi-enzyme complex involving TPP. It requires O2 It is an easily reversible reaction
1.Predict the effect of a large amount of acetyl-CoA on the activity of pyruvate dehydrogenase and...
1.Predict the effect of a large amount of acetyl-CoA on the activity of pyruvate dehydrogenase and the rate of glycolysis. Note: pyruvate dehydrogenase is the enzyme that catalyzes the formation of acetyl-CoA from pyruvate. a. Pyruvate dehydrogenase activity will decrease while the rate of glycolysis will increase. b. Both pyruvate dehydrogenase activity and the rate of glycolysis will decrease. c. Pyruvate dehydrogenase activity will increase while the rate of glycolysis will decrease. d. The rate of glycolysis will increase, thereby,...
I1. Mammals lack the enzyme a. Lactate dehydrogenase b. Pyruvate kinase Alcohol Dehydrogenase c. d. Pyruvate...
I1. Mammals lack the enzyme a. Lactate dehydrogenase b. Pyruvate kinase Alcohol Dehydrogenase c. d. Pyruvate decarboxylase None of the above are correct e. 12. The first reaction of the Krebs cycle combines Oxaloacetate and Acetyl CoA to make Citrate b. a. Malate and NADH to make Citrate a-ketoglutarate and citrate to make CO2 d. c- Succinate and Citrate to make Oxaloacetate 13. The electrons held by NADH and FADH, are donated to the which complexes in the ETC respectively?...
(a) Match a cofactor of pyruvate dehydrogenase with function given in the box. Cofactor A. Coenzyme...
(a) Match a cofactor of pyruvate dehydrogenase with function given in the box. Cofactor A. Coenzyme A (COA-SH) B. NAD C. Thiamine pyrophosphate (TPP) D. FAD E. Lipoamide in oxidized form Functions: Acyl acceptor Electron sink Nucleophile A swinging arm General base ® Oxidizer © Electron conduit Hydrogen atom carrier Reductant (b) Which one of the five steps of the pyruvate dehydrogenase complex reaction is most likely to be metabolically irreversible? Explain.
Which of the following would not be consistent with the pyruvate dehydrogenase complex? aGeneration of NADH...
Which of the following would not be consistent with the pyruvate dehydrogenase complex? aGeneration of NADH and acetyl CoA b. Inhibition of the complex by pyruvate dehydrogenase phosphatase C. Inhibition by acetyl CoA, NADH, and ATP d. Stimulation by phosphoenolpyruvate
15. Genetic defect in pyruvate dehydrogenase complex lead a. maple syrup urine disease b. phenyike d....
15. Genetic defect in pyruvate dehydrogenase complex lead a. maple syrup urine disease b. phenyike d. lactic acidemia e. pellagra syrup urine disease b, phenylketonuria c. galactosemia 10. Chemical modification by phosphorylation of pyruvate dehydros a. deactivates the enzyme b. activates the enzyme lation of pyruvate dehydrogenase complex : 17. Pyruvate carboxylase is positively ated through the allosteric mechanism by : a. ATP b. NADH c. Acetyl-SCOA d. TPP e. Biotin 18. Which of the listed coenzymes does not particip...
4. (20 points) The reaction of pyruvate to acetyl-CoA and CO2 is the bridge reaction between...
4. (20 points) The reaction of pyruvate to acetyl-CoA and CO2 is the bridge reaction between glycolysis and the citric acid cycle. The carbon atoms in pyruvate are numbered and where they end up in the products are indicated CO0Θ 2 C=O + HS-CoA 3 CH3 Pyruvate S-COA 2C=O 3 CH3 Acetyl CoA Pyruvate dehydrogenase +1 CO2 a) Is C atom 1 in CO2 in a more reduced state or more oxidized state compared to its state in pyruvate? Why?...
1. Select the TRUE statement about the citric acid cycle. A. Isocitrate dehydrogenase is a multienzyme...
1. Select the TRUE statement about the citric acid cycle. A. Isocitrate dehydrogenase is a multienzyme complex that is very similar to the pyruvate dehydrogenase complex B. The two decarboxylation steps occur right after each other, first via oxidative alpha- decarboxylation, then via oxidative beta- decarboxylation. C. In one turn of the cycle, the two carbons that enter the cycle as acetyl CoA are the same two carbons that are released as CO2. D. A flavin containing dehydrogenase enzymes oxidizes...
1. The pyruvate dehydrogenase complex converts pyruvate to acetyl-CoA. What are the steps that pyruvate undergoes?...
1. The pyruvate dehydrogenase complex converts pyruvate to acetyl-CoA. What are the steps that pyruvate undergoes? Which coenzymes are involved in each step? 2. Mitochondrial extracts from pigeon breast muscle were incubated with Experiment 1: Amytal, an inhibitor of complex I Experiment 2: Malonate, a competitive inhibitor of succinate dehydrogenase Which experiment will yield more ATP when the cycle is primed with intermediates?
Which of the following answers complete the sentence correctly? The pyruvate dehydrogenase complex is activated by:...
Which of the following answers complete the sentence correctly? The pyruvate dehydrogenase complex is activated by: Select one or more: a. decreased levels of insulin b. phosphorylation of the pyruvate dehydrogenase component E1 c. stimulation of a specific phosphatase by Ca2+ d. decrease of the NADH/NAD+ ratio e. inhibition of a specific kinase by pyruvate
The step in metabolism that converts pyruvate to acetyl-CoA involves pyruvate dehydrogenase complex is shown. NADH NAD Correm A CEO CH co G Pyruvate AwA What is true about this step? ATP is required but not shown The enzyme is a multi-enzyme complex involving TPP. It requires O2 It is an easily reversible reaction
I1. Mammals lack the enzyme a. Lactate dehydrogenase b. Pyruvate kinase Alcohol Dehydrogenase c. d. Pyruvate decarboxylase None of the above are correct e. 12. The first reaction of the Krebs cycle combines Oxaloacetate and Acetyl CoA to make Citrate b. a. Malate and NADH to make Citrate a-ketoglutarate and citrate to make CO2 d. c- Succinate and Citrate to make Oxaloacetate 13. The electrons held by NADH and FADH, are donated to the which complexes in the ETC respectively?...
(a) Match a cofactor of pyruvate dehydrogenase with function given in the box. Cofactor A. Coenzyme A (COA-SH) B. NAD C. Thiamine pyrophosphate (TPP) D. FAD E. Lipoamide in oxidized form Functions: Acyl acceptor Electron sink Nucleophile A swinging arm General base ® Oxidizer © Electron conduit Hydrogen atom carrier Reductant (b) Which one of the five steps of the pyruvate dehydrogenase complex reaction is most likely to be metabolically irreversible? Explain.
Which of the following would not be consistent with the pyruvate dehydrogenase complex? aGeneration of NADH and acetyl CoA b. Inhibition of the complex by pyruvate dehydrogenase phosphatase C. Inhibition by acetyl CoA, NADH, and ATP d. Stimulation by phosphoenolpyruvate
15. Genetic defect in pyruvate dehydrogenase complex lead a. maple syrup urine disease b. phenyike d. lactic acidemia e. pellagra syrup urine disease b, phenylketonuria c. galactosemia 10. Chemical modification by phosphorylation of pyruvate dehydros a. deactivates the enzyme b. activates the enzyme lation of pyruvate dehydrogenase complex : 17. Pyruvate carboxylase is positively ated through the allosteric mechanism by : a. ATP b. NADH c. Acetyl-SCOA d. TPP e. Biotin 18. Which of the listed coenzymes does not particip...
4. (20 points) The reaction of pyruvate to acetyl-CoA and CO2 is the bridge reaction between glycolysis and the citric acid cycle. The carbon atoms in pyruvate are numbered and where they end up in the products are indicated CO0Θ 2 C=O + HS-CoA 3 CH3 Pyruvate S-COA 2C=O 3 CH3 Acetyl CoA Pyruvate dehydrogenase +1 CO2 a) Is C atom 1 in CO2 in a more reduced state or more oxidized state compared to its state in pyruvate? Why?...
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