(find the mechanism in the pic)
2. Propose a mechanism for the Pd-catalyzed cross-coupling of 4-bromochlorobenzene with phenylmagnesium bromide. (3 marks) cat....
(b) The terpyridine ligand 9 can be made using Pd(0) catalyzed cross-coupling reaction. 8 (2 eq.) Sn(Bu)3 Pd(PPhz)4 (cat.), toluene, reflux Br N Br (i) Provide a mechanism for the Pd(0) catalyzed cross-coupling reaction between 7 and 8 that details the complete catalytic cycle for a single substitution process.
Which is the major product of this reaction? Pd cat. Br + -B(OH)2 Оме K2CO3 -Br O A. -Br B. OH C. Meo OH D. Br Compound 1 is an acetyl protected precursor of the phytonutrient pterostilbene (2), a natural antioxidant found in blueberries. Which reagents would you use to synthesize 1 starting with 3 and 4? Brae pana A. Mg B. Po(OAc 2, 2 PPh3,K2CO3 PhBOH12,K2CO3 1.1.2. Cul
The following synthesis is done in 3 steps.
1. The selective oxidation of alcohols.
2. Aromatic Grignard
3. Carbon-Carbon coupling.
Perform stoichiometric calculations to obtain 1 ml of
the final product, using the concept of limit reagent in the
synthesis of geranial and phenylmagnesium bromide. assuming 100%
yield.
The complete equations of the synthesis of geranial and
grignard reagent are shown below. (They are needed to calculate the
final 1 ml of product of the reaction above)
Density of Final...
2. Briefly explain why ethanol, and not hexane, was used as a solvent in this reaction? 3. Why it is necessary to filter the crude coupling product through a column of anhydrous MgSO4? 4. Briefly explain why aryl bromides and iodides, rather than aryl chlorides or fluorides, are typically used as substrates in Pd-catalyzed coupling reactions. 5. Propose a synthesis for the molecule A shown below, using benzene, phenyl boronic acid, tert-butyl bromide and any inorganic reagents needed. A retrosynthetic...
3. Propose a mechanism for TWO of the THREE reactions below, showing the movement of every pair of electrons for the two that you select (12 pts). Name the TWO reactions for which you proposed a mechanism (4 pts). a. b. Br NASCH(CH3)2 acetone 1. H . MgBr HO ether H 2. HCI
please draw a step-wise mechanism for the reacrion between 1-iodo-4-nitrobenze and 2-methyl-3-butyn-2-ol with the reagents Pd(PPh3)2Cl2 , Cul, Et3N.
Show the steps (don't show mechanism)
Ex. 2: Propose a synthesis for the following transformations: a) 1. CI 2. Jones OH 3. Hz. Pd/C Н HO OH I
g. Ph-C(O)-NH2 4 NaOH Br2 h. (HC)2CH-C(CHa)2 -> HO N(CH3)3 i. Ph-N2, CI- + CuCN --> H30* (cat) Na/ETOH j. cyclohexanone+ H2NOH Pd(OAc)2 (1 mole%) k. Ph-I + 4-O2N-C&H4-HC=CH2 Cul/Pd(PPH3)4) L. HO-CH2-CH2-CC-H +1-CH=CH-(CH2)4-CH3
can someone do 1-3?
Pechmann Condensation 1. Propose a mechanism for the acid-catalyzed Pechmann condensation of resorcinol and ethyl acetoacetate. Identify the transesterification, electrophilic aromatic substitution and dehydration steps. 2. Would you expect 1,3,5-trihydroxybenzene (phloroglucinol) to react more quickly or more slowly than resorcinol? Why or why not? 3. Consider and discuss the greenness of Pechmann Reaction. 4. Discuss and assign the peaks (chemical shift, splitting pattern, etc) in the 1H NMR and IR spectra of your product INDO,
What's the mechanism of this reaction?
HOA VOE- Ph Br 1) NaN3 2) H2, Pd-C ELUL CH3 3) 2 eq. CH20, 2 eq. NaBH3CN 4) H2O2 5) heat