Question

Can you please help me fill in the blanks and explain what is happening here?

In eukaryotes the enhancer can be 5’ or 3’ of the promoter, and even far away because it can ____________ to the promoter. When it does, the _________________ bound at the enhancer can interact with the RNA polymerase. Transcriptional repressors can compete with transcriptional activators for ________ motifs in the enhancer and thus block binding of the transcriptional activator. It can also mask the ______________between the transcriptional activators and RNA polymerase thus preventing polymerase recruitment. Finally, many transcriptional repressors can recruit histone deacetylases or DNA methylases to the chromatin to ___________it, which also prevents transcription.

Answer 1

Enhancers can come close to the promoter. Enhancers are located distance away from the promoter. It can however contact the promoter by looping out of the DNA between the two sequences.

the transcriptional activator bound at the enhancer can interact with RNA polymerase.

Transcriptional repressor can compete with activator  for sequence motif in the enhancer, thus blocking binding of transcriptional activator

Transcriptional repressor also the mask interaction between transcriptional activator and RNA polymerase

transcriptional repressors can recruit histone deacteylase and DNA methylases to the chromatin to compact it, which also prevent transcriptional