Question

6.11. Calculate the equilibrium allele frequency (9-) for each of the following fitness sets. Assume 110° in each case. What is the effect of partial dominance on the mutation-selection equilibrium? Explain in biological terms. (hint: use dominance model for fitness, 1. l-hs, 1-5) WI 1 0 .95 10.90 0.9 0.9 0.98 0.99 098

This is Population Genetics.

Answer 1

Answer :)

To calculate allele frequency, use the following method:

Suppose each genotype frequency is in the share of x.

In fitness set a, if the frequency is in equilibrium:

W11(x) + W12(x) + W22(x) = 1

1x + 1x + 0.9x = 1

2.9x = 1

X = 1/2.9

X = 0.345

W11 is the fitness of genotype AA, which has frequency 0.345.

Therefore, allele frequency A (p) = square root of 0.345

Allele frequency A (p) = 0.587

Therefore, allele frequency of recessive allele a (q) = 1 – 0.587

Allele frequency of recessive allele a (q) = 0.413

That is how we proceed for each set,

Again in the set b:

W11(x) + W12(x) + W22(x) = 1

1x + 0.95x + 0.9x = 1

2.85x = 1

X = 1/2.85

X = 0.35

Therefore, allele frequency A (p) = square root of 0.35

Allele frequency A (p) = 0.59

Therefore, allele frequency of recessive allele a (q) = 1 – 0.59

Allele frequency of recessive allele a (q) = 0.41

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