Question

Likewise, the second group of CDKI that function throughout the cell cycle are negatively regulated by growth factor signaling, which result in their inactivation or destruction. What post-translational modification mediates their suppression, and what are two consequences of such modification?

Modification: ___________________________________.

Consequences: 1. _____________________________________________ 2. _________________________________

Answer 1

The second group of CDKI inhibits cyclin-dependent kinase. The second group of CDKI that function throughout the cell cycle are negatively regulated by growth factor signaling, which result in their inactivation or destruction. The second group of CdkIs is known as the INK4 family. p27 is the main member of CDKI family. Its expression is regulated by cell contact inhibition. It is a putative tumor

Modification: It involves modification of the side chains of the amino acid residues and they do'nt interfere with the polypeptide backbone.

Consequences:1. The post translational modification regulates the biochemical process with the enzymatic activity.

2. lack of methylation maintenance during DNA replication.